Prospects for the use of nanozyme-based electrochemical and colorimetric sensors for antibiotic detection

Rapid and accurate monitoring of residual antibiotic concentrations is of great importance in environmental monitoring. Therefore, research is active to develop new methods for analyzing antibiotics. Biosensors, including those based on nanozymes, are very successful for antibiotic analysis. Nanozymes (nanomaterials with enzymelike activity) have emerged as a promising solution offering improved stability, cost-effectiveness, and versatility, as compared with natural enzymes. The use of nanozyme-based electrochemical and colorimetric sensors for detecting antibiotics remains underexplored. This review presents the main prospects for the use of electrochemical and colorimetric nanozyme sensor systems to detect antibiotics. It identifies major shortcomings of these platforms and ways to deal with them. Finally, it highlights the advantages of these sensors over other systems and explains the main mechanisms of signal generation for antibiotic detection.