Oocytes Quality Assessment-The Current Insight: A Systematic Review.

Area of Science:

• Reproductive Medicine
• Embryology
• In Vitro Fertilization

Background:

• In vitro fertilization (IVF) outcomes are influenced by oocyte quality.
• Standardized oocyte quality assessment (OQA) methods are lacking due to inconclusive evidence.
• Consolidating OQA strategies is necessary for improved IVF success rates.

Purpose of the Study:

• To summarize current OQA methods used in IVF.
• To compare the efficacy and applicability of different OQA techniques.
• To identify the optimal OQA strategy for clinical implementation and cost-effectiveness.

Main Methods:

• Systematic review and comparison of existing OQA methodologies.
• Evaluation of methods including morphological assessment, follicular fluid analysis, mitochondria spindle assessment, and live zona imaging.
• Analysis of cost-effectiveness, precision, and clinical applicability.

Main Results:

• Morphological assessment is identified as the most cost-effective and clinically implementable OQA method.
• Total oocyte scoring is the most frequently utilized method.
• Advanced techniques like follicular fluid evaluation, mitochondria spindle assessment, and live zona imaging offer higher precision but are limited by cost and expertise, making them suitable for research or specialized centers.

Conclusions:

• Morphological assessment provides a reproducible and cost-effective approach to OQA in IVF.
• While advanced methods show promise, current evidence supports morphological assessment for widespread clinical use.
• Optimized OQA strategies are essential for enhancing IVF outcomes and clinical implementation.