Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heparin therapy adjusted for body weight.

I Talstad

    American Journal of Clinical Pathology
    |March 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    This study found a linear relationship between heparin dosage and blood concentrations. Therapeutic heparin levels were achieved in 78% of patients with a specific dosing regimen, but daily monitoring is crucial.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Why is the standardization of prothrombin time a problem?

    Haemostasis·2001
    Same author

    [Cardiac natriuretic peptides as markers of left ventricular dysfunction].

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·1997
    Same author

    [Do you treat your vitamin B12 patients correctly?].

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·1996
    Same author

    [Homocysteine and methylmalonic acid. New tests--for what benefit?].

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·1996
    Same author

    Prothrombin time standardization by correction of the Pivka inhibitor.

    Haemostasis·1996
    Same author

    [Do you treat your vitamin B 12 patients correctly?].

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·1996

    Area of Science:

    • Pharmacology
    • Biochemistry

    Background:

    • Heparin is a critical anticoagulant medication.
    • Understanding heparin pharmacokinetics is essential for safe and effective use.

    Purpose of the Study:

    • To investigate the linear relationship between heparin dosage and plasma concentrations.
    • To evaluate a specific heparin dosing regimen for therapeutic efficacy.

    Main Methods:

    • Assessing heparin concentrations in plasma after bolus injections and during maintenance therapy.
    • Correlating heparin dosage (units/kg body weight) with observed plasma levels.
    • Evaluating a therapeutic regimen involving a bolus dose followed by continuous infusion.

    Main Results:

    • A strong linear correlation (r = 0.91) was observed between heparin dosage and plasma concentrations post-bolus injection.

    Related Experiment Videos

  • Maintenance therapy also demonstrated linearity, but patient sensitivity varied.
  • A regimen of 75 U/kg bolus followed by 400 U/kg/24 hours achieved therapeutic response in 78% of patients.

    • Conclusions:

    • Heparin dosage is linearly related to plasma concentrations, supporting dose-based adjustments.
    • Individualized heparin monitoring is necessary due to inter-patient variability in response.
    • A defined dosing strategy can achieve therapeutic levels, but requires vigilant monitoring for optimal anticoagulation.