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Updated: Jun 3, 2025

Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis
Published on: July 11, 2014
Optimizing Recovery of High-Added-Value Compounds from Complex Food Matrices Using Multivariate Methods
Yixuan Liu1, Basharat N Dar2, Hilal A Makroo2
1Research Group in Innovative Technologies for Sustainable Food (ALISOST), Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine Department, Faculty of Pharmacy, Universitat de València, Avda. Vicent Andrés Estellés, s/n, 46100 Burjassot, Spain.
Abstract:
In today's food industry, optimizing the recovery of high-value compounds is crucial for enhancing quality and yield. Multivariate methods like Response Surface Methodology (RSM) and Artificial Neural Networks (ANNs) play key roles in achieving this. This review compares their technical strengths and examines their sustainability impacts, highlighting how these methods support greener food processing by optimizing resources and reducing waste. RSM is valued for its structured approach to modeling complex processes, while ANNs excel in handling nonlinear relationships and large datasets. Combining RSM and ANNs offers a powerful, synergistic approach to improving predictive models, helping to preserve nutrients and extend shelf life. The review emphasizes the potential of RSM and ANNs to drive innovation and sustainability in the food industry, with further exploration needed for scalability and integration with emerging technologies.
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