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Apriliana Ellya Ratna Kartikasari1, Paul Michel-Lara2, Hayden Exton1

  • 1Cancer, Ageing, and Vaccine Research Group (CAVA), School of Health and Biomedical Sciences, RMIT University, Bundoora 3083, Australia.

Cancers
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PubMed

Keywords:
circulating biomarkerdiagnosismicroRNAsovarian cancerpersonalized therapy

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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