Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

7.3K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.3K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

7.2K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.2K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.2K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.2K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

8.7K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
8.7K
Notch Signaling Pathway03:14

Notch Signaling Pathway

4.2K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expanding the spectrum of non-canonical NUT carcinoma: clinicopathological and molecular characterization of <i>BRD3::NUTM1</i> and <i>WWTR1::NUTM1</i> fusion variants.

Frontiers in oncology·2026
Same author

Tunable Narrow-Linewidth Si<sub>3</sub>N<sub>4</sub> External-Cavity Semiconductor Laser Based on an Asymmetric Bezier Triple-Ring Resonator.

Sensors (Basel, Switzerland)·2026
Same author

A Principle-Guided Multistep Workflow for Screening Potential Quality Marker Candidates of Sanqi Shangyao Tablet Based on UHPLC-Q-Orbitrap MS, In Silico Screening, and In Vitro Validation.

Biomedical chromatography : BMC·2026
Same author

Integrated prioritization of candidate quality markers for Smilacis Chinae Rhizoma under the five-principle framework through chemical profiling, effectiveness evaluation, and bionic sensing.

Journal of ethnopharmacology·2026
Same author

From electron supply to electron economy: a unified framework for N<sub>2</sub>O control in membrane aerated biofilm reactors.

Water research·2026
Same author

Polyamine-Related Gene Families Identification and Regulatory Effects on Early Somatic Embryogenesis via Modulating Gene Expressions and Hormone Levels in <i>Ginkgo biloba</i>.

Plants (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jun 3, 2025

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

462

Hedgehog Signaling Pathway in Fibrosis and Targeted Therapies.

Yuchen Hu1,2, Linrui Peng1,2, Xinyu Zhuo1,2

  • 1Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.

Biomolecules
|January 8, 2025
PubMed
Summary

Hedgehog (Hh) signaling, vital for development, is increasingly linked to fibrotic diseases. This review explores Hh signaling

Keywords:
fibrosishedgehog signaling pathwaytargeted therapies

More Related Videos

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

7.2K
A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

4.4K

Related Experiment Videos

Last Updated: Jun 3, 2025

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

462
Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

7.2K
A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

4.4K

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Pathology

Background:

  • Hedgehog (Hh) signaling is a critical developmental pathway.
  • Dysregulated Hh signaling contributes to fibrotic diseases, marked by excessive extracellular matrix deposition.
  • Understanding Hh's role in fibrosis is advancing, with targeted inhibitors in trials.

Purpose of the Study:

  • To provide an overview of Hh signaling mechanisms.
  • To summarize Hh signaling's role in fibrogenesis across various organs.
  • To highlight tissue-specific variations and therapeutic challenges.

Main Methods:

  • Literature review of Hh signaling pathways.
  • Analysis of Hh's involvement in liver, kidney, lung, and airway fibrosis.
  • Examination of Hh-targeted therapies for fibrotic conditions.

Main Results:

  • Hh signaling plays a complex role in fibrogenesis.
  • Distinct functional variations of Hh signaling exist across different organs.
  • Hh pathway context dependence is crucial for understanding its fibrotic role.

Conclusions:

  • Hh signaling is a key player in fibrotic diseases.
  • Therapeutic strategies targeting Hh require consideration of organ-specific contexts.
  • Challenges remain in developing effective Hh-targeted antifibrotic therapies.