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Urinary Tract Infections Detection with Molecular Biomarkers
Jiayi Sun1, Kai Cheng2, Yanyun Xie3
1Xiangya Hospital, Central South University, Changsha 410008, China.
Biomolecules
|January 8, 2025
Summary
Urinary tract infection (UTI) diagnosis needs better biomarkers. This review categorizes UTI biomarkers, highlighting nucleic acid, metabolomic, and lipidomic types for improved detection.
Area of Science:
- Medical Diagnostics
- Infectious Diseases
- Biomarker Research
Background:
- Urinary tract infection (UTI) is a common bacterial infection.
- Current diagnostic methods like urine culture, PCR, flow cytometry, and lateral flow immunoassay have limitations including workload, time consumption, and low sensitivity.
- There is an urgent need for reliable biomarkers for effective UTI diagnosis.
Purpose of the Study:
- To review and categorize existing and potential biomarkers for diagnosing urinary tract infections (UTIs).
- To highlight nucleic acid-associated, metabolomic, and lipidomic biomarkers.
- To discuss the challenges and future prospects of UTI biomarkers.
Main Methods:
- Literature review of existing studies on UTI biomarkers.
- Classification of biomarkers into clinically used, promising, and controversial categories.
- Focus on specific biomarker types: nucleic acid-associated, metabolomic, and lipidomic.
Main Results:
- UTI definitions and classifications (uncomplicated/complicated, lower/upper) were considered.
- Biomarkers were categorized based on current clinical use, promise, and controversy.
- Nucleic acid-associated, metabolomic, and lipidomic biomarkers show particular potential.
Conclusions:
- Reliable biomarkers are crucial for improving UTI diagnosis and reducing laboratory workload.
- Further research into categorized biomarkers, especially nucleic acid, metabolomic, and lipidomic types, is warranted.
- Addressing challenges in biomarker development will enhance UTI diagnostic strategies.
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