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Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx
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Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx

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358

Role of the Receptor for Advanced Glycation End Products (RAGE) and Its Ligands in Inflammatory Responses

Kaylen Cross1, Stefan W Vetter1, Yousuf Alam1

  • 1Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58105, USA.

Biomolecules
|January 8, 2025
PubMed

Insights

The receptor for advanced glycation end products (RAGE) is crucial in inflammation, activated by diverse ligands like damage-associated molecular patterns (DAMPs). Further research is needed to clarify RAGE activation mechanisms.

Area of Science:

  • Immunology
  • Molecular Biology
  • Pathology

Background:

  • The receptor for advanced glycation end products (RAGE) was discovered in 1992.
  • RAGE is implicated in numerous pathological conditions, particularly inflammatory diseases.
  • It is expressed on most immune cells and activated by a wide array of structurally diverse ligands.

Purpose of the Study:

  • To review the current understanding of RAGE's role in inflammation.
  • To explore the diverse ligands that activate RAGE.
  • To highlight the need for further research into RAGE activation mechanisms.

Main Methods:

  • Literature review of research on RAGE and its ligands.
  • Summary of known RAGE ligands, including damage-associated molecular patterns (DAMPs).
  • Analysis of RAGE expression on immune cells.

Main Results:

  • RAGE is a promiscuous receptor, binding to structurally diverse ligands.
  • Many RAGE ligands are DAMPs released during inflammation.
  • Despite extensive research, RAGE activation mechanisms remain unclear.

Conclusions:

  • RAGE plays a significant role in inflammatory processes.
  • The diverse nature of RAGE ligands contributes to its complex function.
  • Elucidating RAGE activation mechanisms is essential for understanding inflammatory diseases.
Keywords:
DAMPRAGES100inflammationstress

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