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Updated: May 20, 2026

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
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Relationship Between DWI-Based Acute Ischemic Stroke Volume, Location and Severity of Dysphagia

Carlo A Mallio1,2, Daniele Vertulli1,2, Gianfranco Di Gennaro3

  • 1Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy.

Brain Sciences
|January 8, 2025
PubMed
Abstract

Insights

Stroke location and volume significantly impact post-stroke dysphagia severity. Larger ischemic volumes correlate with worse swallowing function, as measured by DOSS and P-score.

Area of Science:

  • Neurology
  • Radiology
  • Speech-Language Pathology

Background:

  • Post-stroke dysphagia is a common complication affecting patient recovery and quality of life.
  • The precise relationship between the characteristics of acute ischemic brain lesions and dysphagia severity remains incompletely understood.

Purpose of the Study:

  • To investigate the association between acute ischemic lesion volume and location and the severity of post-stroke dysphagia.
  • To quantify the relationship between brain MRI findings and clinical dysphagia assessments.

Main Methods:

  • Sixty-four stroke patients underwent 1.5 Tesla brain MRI with diffusion-weighted imaging (DWI) to determine acute ischemic volume.
  • Dysphagia severity was assessed by a multidisciplinary team using the Dysphagia Outcome and Severity Scale (DOSS), Penetration-Aspiration Scale (PAS), and Pooling score (P-score).

Main Results:

  • A significant negative correlation was found between total ischemic volume and the DOSS (r = -0.441, p = 0.0003).
  • A significant positive correlation was observed between total ischemic volume and the P-score (rs = 0.3054, p = 0.0328).
  • These findings suggest that larger acute ischemic volumes are associated with more severe dysphagia.

Conclusions:

  • Quantitative DWI-based data on acute ischemic volume and anatomical location are significantly associated with dysphagia severity.
  • These findings highlight the importance of lesion characteristics in predicting and managing post-stroke swallowing difficulties.
Keywords:
DWIMRIbraindysphagiastroke

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