5-Hydroxytryptamine G-Protein-Coupled Receptor Family Genes: Key Players in Cancer Prognosis, Immune Regulation, and Therapeutic Response
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View abstract on PubMed
Summary
This summary is machine-generated.5-hydroxytryptamine G-protein-coupled receptors (HTGPCRs) show altered expression in cancers and correlate with patient prognosis and tumor microenvironments. These HTGPCRs offer potential as prognostic indicators and therapeutic targets for various malignancies.
Area Of Science
- Oncology
- Genetics
- Molecular Biology
Background
- 5-hydroxytryptamine G-protein-coupled receptors (HTGPCRs), a family of 13 genes, are implicated in cancer progression.
- A comprehensive understanding of HTGPCRs' role in diverse cancers is currently lacking.
Purpose Of The Study
- To investigate the gene expression levels and prognostic significance of HTGPCRs across various cancer types (pan-cancer analysis).
- To explore the associations between HTGPCR expression and clinical characteristics, immune subtypes, stemness, tumor microenvironments (TMEs), and drug sensitivity.
Main Methods
- Pan-cancer analysis of HTGPCR gene expression and prognostic values.
- Correlation analysis with clinical features, immune profiles, stemness scores, TMEs, and drug sensitivity.
- Single-cell analysis and experimental validation (e.g., gene knockdown in breast cancer).
Main Results
- Significant differences in HTGPCR expression were observed between normal tissues and tumors, with specific genes like HTR1D/2C overexpressed in several cancers (e.g., BRCA, liver cancer).
- HTGPCR expression correlated with prognosis, stemness, TMB, MSI, and TME components, and was linked to immune cells and checkpoint genes.
- Single-cell analysis revealed HTGPCR gene set correlations with cancer-related functions in retinoblastoma; HTR4 correlated with drug sensitivity, and HTR1D knockdown inhibited breast cancer growth.
Conclusions
- HTGPCRs demonstrate significant potential as prognostic indicators in various cancers.
- These receptors offer valuable insights for developing novel therapeutic strategies against malignancies.
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