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Cell Specific Gene Expression

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...

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Updated: Jun 3, 2025

Single-cell Transcriptomic Analyses of Mouse Pancreatic Endocrine Cells

Single-cell Transcriptomic Analyses of Mouse Pancreatic Endocrine Cells

Published on: September 30, 2018

Exploring the Molecular Link Between Diabetes and Erectile Dysfunction Through Single-Cell Transcriptome Analysis.

Mahmuda Begum¹, Mayank Choubey², Munichandra Babu Tirumalasetty²

¹Department of Internal Medicine, HCA-St. David's Medical Center, 919 E 32nd St, Austin, TX 78705, USA.

|January 8, 2025

Summary

Diabetic men often experience erectile dysfunction (ED). This study reanalyzed transcriptomic data, revealing altered adiponectin receptor expression in ED, suggesting new therapeutic targets for diabetes-associated male infertility.

Keywords:

diabetes diabetic sexual health erectile dysfunction human single-cell transcriptome data men’s sexual health microvascular complications single-cell analysis

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Last Updated: Jun 3, 2025

Single-cell Transcriptomic Analyses of Mouse Pancreatic Endocrine Cells

Single-cell Transcriptomic Analyses of Mouse Pancreatic Endocrine Cells

Published on: September 30, 2018

A Method for Mouse Pancreatic Islet Isolation and Intracellular cAMP Determination

A Method for Mouse Pancreatic Islet Isolation and Intracellular cAMP Determination

Published on: June 25, 2014

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Published on: July 18, 2019

Area of Science:

Urology
Endocrinology
Molecular Biology

Background:

Erectile dysfunction (ED) affects 35-75% of diabetic men globally.
Diabetes-associated ED mechanisms, particularly nerve and vascular damage, are not fully understood.
Existing research suggests multifactorial causes for ED in diabetic individuals.

Purpose of the Study:

To reanalyze human single-cell transcriptomic data from diabetic men with ED.
To identify molecular and cellular alterations contributing to diabetes-associated ED.
To explore potential therapeutic targets for ED and male infertility in diabetes.

Main Methods:

Reanalysis of existing human single-cell transcriptomic data.
Comparative analysis of gene expression in healthy individuals versus those with diabetes-associated ED.
Focus on genes related to antioxidative pathways, growth factors, angiogenesis, and inflammation.

Main Results:

Validated expression of genes involved in sexual function, vascular health, and inflammation.
Identified significant alterations in adiponectin receptor expression in diabetic ED.
Transcriptomic data revealed distinct cellular profiles between healthy and ED subjects.

Conclusions:

Adiponectin receptor alterations are implicated in the pathogenesis of diabetes-associated ED.
Understanding these molecular underpinnings can guide targeted therapeutic strategies.
This review provides insights into cellular mechanisms of ED, potentially impacting diabetes-associated male infertility treatments.