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Impact of Long-Term Cannabidiol (CBD) Treatment on Mouse Kidney Transcriptome
Mikołaj Rokicki1, Jakub Żurowski1, Sebastian Sawicki2
1Department of Basic Sciences, Faculty of Veterinary Medicine, University of Agriculture in Kraków, Redzina 1C, 30-248 Krakow, Poland.
Genes
|January 8, 2025
Summary
Long-term cannabidiol (CBD) treatment impacts kidney gene expression in mice, affecting circadian rhythm, lipid metabolism, and inflammation. These findings suggest CBD
Area of Science:
- Pharmacology
- Genomics
- Nephrology
Background:
- Cannabidiol (CBD), a key compound from Cannabis sativa, exhibits anti-inflammatory and antioxidant properties.
- These properties suggest potential therapeutic applications for various kidney conditions.
Purpose of the Study:
- To investigate the long-term effects of cannabidiol (CBD) on the renal transcriptome in a mouse model.
- To determine if systematic CBD treatment influences kidney gene expression.
Main Methods:
- Male C57BL/6J mice received daily intraperitoneal injections of CBD (10 mg/kg or 20 mg/kg) for 28 days.
- Kidney tissues were collected post-treatment for RNA isolation and RNA-Seq sequencing.
Main Results:
- CBD treatment altered gene expression in mouse kidneys.
- Affected pathways include circadian rhythm, glucocorticoid receptor function, lipid metabolism, and inflammatory response.
- Specific genes regulated by CBD were identified within these pathways.
Conclusions:
- CBD demonstrates potential benefits for kidney disease treatment.
- Further clinical trials are warranted to validate these findings.
