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Mitigating Oxidative Stress and Promoting Cellular Longevity with Mushroom Extracts.

Menna-Allah E Abdelkader1,2, Hatungimana Mediatrice1,3, Dongmei Lin1

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Medicinal mushrooms like Agaricus bisporus and Hericium erinaceus show potent antioxidant and anti-aging benefits. Extracts promote cell proliferation, DNA synthesis, and reduce oxidative stress, suggesting natural anti-aging potential.

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Area of Science:

  • * Mycology and Biochemistry
  • * Cell Biology and Aging Research
  • * Natural Product Chemistry

Background:

  • * Oxidative stress, caused by free radicals, accelerates aging and contributes to health issues.
  • * Medicinal and edible mushrooms are recognized for their potential health-promoting properties.
  • * Understanding the antioxidant and anti-aging mechanisms of mushrooms is crucial for developing natural interventions.

Purpose of the Study:

  • * To evaluate the antioxidant and anti-aging potential of four mushroom species: Ganoderma lucidum, Hericium erinaceus, Pleurotus ostreatus, and Agaricus bisporus.
  • * To assess the effects of mushroom extracts on cellular processes related to aging in vitro.
  • * To investigate the immunomodulatory and anti-inflammatory activities of these mushroom extracts.

Main Methods:

  • * Antioxidant activity assessed using DPPH, ABTS, and reducing power assays.
  • * Anti-aging effects evaluated on D-galactose-induced aged Human Skin Fibroblasts (HSF) cells.
  • * Cell proliferation, cell cycle progression, DNA synthesis, DNA damage, and Reactive Oxygen Species (ROS) levels were measured.
  • * Immunomodulatory effects assessed by analyzing Interleukin (IL)-2, IL-4, and IL-6 expression.

Main Results:

  • * All tested mushroom extracts exhibited significant antioxidant and anti-aging properties.
  • * Agaricus bisporus extract (0.03 mg/mL) promoted cell proliferation by 87%.
  • * Hericium erinaceus extract (0.03 mg/mL) enhanced cell cycle progression and DNA synthesis.
  • * Extracts reduced DNA damage and ROS levels, mitigating oxidative stress.
  • * Mushroom extracts demonstrated immunomodulatory effects by upregulating IL-2/IL-4 and downregulating IL-6.

Conclusions:

  • * Mushroom extracts possess significant antioxidant and anti-aging capabilities, offering protection against oxidative stress.
  • * These natural agents can promote cellular health by enhancing proliferation, cell cycle progression, and DNA synthesis.
  • * The immunomodulatory and anti-inflammatory effects further support the potential of mushrooms for overall health promotion.
  • * Further research into specific bioactive compounds and in vivo efficacy is warranted.