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Temporary Flow Diversion in Oncological Embolization Procedures Using Degradable Starch Microspheres.

Francesco Giurazza1, Pierleone Lucatelli2, Fabio Corvino1

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Degradable starch microspheres safely and effectively divert blood flow in oncologic embolization when selective vessel access is impossible. This method protects healthy tissues during cancer treatment, achieving high clinical success rates.

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Area of Science:

  • Interventional Radiology
  • Oncology
  • Vascular Surgery

Background:

  • Selective catheterization of tumor-feeding vessels is crucial in oncologic embolization.
  • Challenges arise when superselective catheterism is unfeasible, risking damage to healthy tissues.
  • Temporary flow diversion offers a potential solution to protect non-target organs.

Purpose of the Study:

  • To evaluate the safety and efficacy of degradable starch microspheres for temporary flow diversion in oncologic embolization.
  • To assess the utility of this technique when selective tumor vessel access is not possible.
  • To determine the technical and clinical success rates and complication profile.

Main Methods:

  • Multicenter retrospective analysis of 16 patients undergoing visceral embolization for malignancies.
  • Inclusion criteria: flow diversion with degradable starch microspheres, unfeasible superselective catheterism, and malignant pathology.
  • Technical success: complete flow diversion and successful target embolization. Clinical success: procedural achievement and patient improvement.

Main Results:

  • 100% technical success in achieving flow diversion.
  • 87.5% clinical success rate, with two cases showing partial response.
  • Minor complications occurred in 31.2% of patients.

Conclusions:

  • Degradable starch microspheres are a safe and effective tool for temporary flow diversion in oncologic embolization.
  • This technique is valuable for protecting healthy tissues when target vessels are not selectively accessible.
  • The method facilitates embolization in complex oncological cases.