Prognostic Utility of the Modified Systemic Inflammation Score for Patients Undergoing Oral Cavity Cancer Surgery

Area of Science:

• Oncology
• Inflammation research
• Surgical oncology

Background:

• Chronic inflammation is a key factor in cancer development.
• Oral cavity squamous cell carcinoma (OCSCC) prognosis requires better predictive tools.

Purpose of the Study:

• To evaluate the prognostic value of the preoperative modified systemic inflammation score (mSIS) in OCSCC patients.
• To assess the association between mSIS and overall survival (OS) and disease-free survival (DFS).

Main Methods:

• Retrospective analysis of 320 OCSCC patients undergoing curative surgery.
• Classification into three mSIS groups (0, 1, 2) based on lymphocyte-to-monocyte ratio (LMR) and serum albumin.
• Development of a nomogram for OS prediction using mSIS.

Main Results:

• mSIS groups showed a significant trend of decreasing OS and DFS (p < 0.001).
• mSIS scores of 1 and 2 were independent negative prognostic indicators.
• The mSIS-based nomogram demonstrated good OS prediction accuracy (concordance index: 0.755).

Conclusions:

• The preoperative mSIS is a reliable predictor of OS and DFS in surgically treated OCSCC patients.
• An mSIS-based nomogram enhances clinical utility by providing individualized OS estimates.
• mSIS offers valuable prognostic information for OCSCC management.