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Updated: Jun 3, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

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Published on: January 12, 2020

Evaluation of BRIP-1 (FANCJ) and FANCI Protein Expression in Ovarian Cancer Tissue.

Mateusz Kozłowski¹, Dominika Borzyszkowska¹, Anna Golara¹

¹Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.

|January 8, 2025

Summary

FANCI and BRIP-1 (FANCJ) protein expression in ovarian cancer tissues may help differentiate clinical features. Lower FANCI expression is linked to lower FIGO stage ovarian cancer.

Keywords:

BRIP-1 FANCI FANCJ HGSOC expression marker ovarian cancer

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Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity

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Published on: December 31, 2015

Area of Science:

Oncology
Molecular Biology
Biochemistry

Background:

Ovarian cancer remains a significant health concern for women globally.
Identifying reliable biomarkers for ovarian cancer is crucial for improved patient outcomes.
Current research seeks novel markers to aid in diagnosis and prognosis.

Purpose of the Study:

To investigate the expression levels of BRIP-1 (also known as FANCJ) and FANCI proteins in ovarian cancer tissues.
To determine the correlation between the expression of these proteins and various clinical features of ovarian cancer.
To assess the potential of FANCI and BRIP-1 as diagnostic or prognostic markers.

Main Methods:

The study included 68 patients diagnosed with ovarian cancer.
Immunohistochemical techniques were employed to evaluate FANCI and BRIP-1 protein expression in tumor samples.
Patients were categorized into high-grade serous ovarian cancer (HGSOC) and non-HGSOC groups for comparative analysis.

Main Results:

FANCI protein predominantly exhibited moderate to strong positive expression.
BRIP-1 (FANCJ) protein mostly showed no or positive expression.
Lower expression levels of both FANCI and BRIP-1 were associated with differences in clinical stage for HGSOC, and lower BRIP-1 expression correlated with menopausal status.

Conclusions:

FANCI protein expression serves as a potential marker associated with lower FIGO stage and high-grade histology in ovarian cancers.
The findings suggest that FANCI and BRIP-1 protein expression patterns may offer insights into ovarian cancer characteristics.
Further research is warranted to fully elucidate the clinical utility of these proteins in ovarian cancer management.