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Related Experiment Video

Updated: May 16, 2026

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Could CH₃-M6P Be a Potential Dual-Functioning Candidate for Bone Regeneration?

Fidan Huseynova^1,2,3, Cătălina Ionescu⁴, Frederic Cuisinier^1,5,6

¹LBN, Montpellier University, 34193 Montpellier, France.

|January 8, 2025

Summary

This summary is machine-generated.

A novel M6P derivative, CH3-M6P, shows promise for bone regeneration by upregulating key osteogenic genes and exhibiting angiogenic effects. Further research may lead to new bone-forming drugs and dual-functionality in tissue engineering.

Keywords:

CH3-M6P DPSC angiogenesis bone formation gene expression stem cell

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Last Updated: May 16, 2026

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Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

Area of Science:

Biomaterials Science
Regenerative Medicine
Molecular Biology

Background:

CI-RM6P interacts with M6P and IGF2, regulating TGF-β and IGF pathways crucial for cell growth.
A synthesized M6P derivative, CH3-M6P, was investigated as a potential candidate for bone tissue regeneration.
The study aimed to assess CH3-M6P's efficacy based on binding affinity, serum stability, cost, and delivery.

Purpose of the Study:

To synthesize and evaluate a novel M6P derivative (CH3-M6P) for bone tissue regeneration.
To assess the molecule's effects on osteogenic differentiation and angiogenic potential.
To explore its potential as a dual-functioning agent in bone tissue engineering.

Main Methods:

Synthesis of CH3-M6P.
Assessment of dental pulp stem cells (DPSCs) origin, alkaline phosphatase (ALP) activity, and gene expression (qPCR).
Immunofluorescence, SEM/EDS for matrix formation, and rat aortic ring assay for angiogenesis.

Main Results:

CH3-M6P upregulated ALP activity and key osteogenic genes (ALP, Col1, RunX2, Mef2C, TGFβ1, TGFβ1R, TGFβ2, Smad3).
No enhancement in organic or inorganic matrix formation was observed via immunofluorescence and SEM/EDS.
CH3-M6P demonstrated significant angiogenic effects, comparable to VEGF, by inducing angiogenic genes.

Conclusions:

CH3-M6P shows potential for enhancing osteomedium capabilities and developing bone-forming drugs.
The molecule exhibits dual functionality, promoting both osteogenesis and angiogenesis.
Further exploration is warranted to optimize its application in bone tissue engineering.