Overview of the Trending Enteric Viruses and Their Pathogenesis in Intestinal Epithelial Cell Infection

Area of Science:

• Virology
• Public Health
• Gastroenterology

Background:

• Enteric virus infections are a significant global health concern, causing widespread diarrheal disease, particularly in young children.
• These viruses spread through the fecal-oral route and can lead to severe illness and death, with unclear pathogenic mechanisms.
• The gastrointestinal effects of SARS-CoV-2 are also a growing concern, necessitating further investigation.

Purpose of the Study:

• To review and organize current research on prevalent enteric virus infections.
• To discuss the pathogenic mechanisms of key enteric viruses including rotavirus, norovirus, adenovirus, Enterovirus-A71, Coxsackievirus A6, and Echovirus 11.
• To explore the gastrointestinal pathogenesis of SARS-CoV-2 in intestinal epithelial cells.

Main Methods:

• Comprehensive literature review of studies on enteric virus infections.
• Analysis of pathogenic mechanisms of selected enteric viruses.
• Examination of SARS-CoV-2's effects on intestinal epithelial cells.

Main Results:

• Identified rotavirus, norovirus, adenovirus, Enterovirus-A71, Coxsackievirus A6, and Echovirus 11 as significant enteric pathogens.
• Highlighted the fecal-oral transmission route and common gastrointestinal symptoms.
• Underscored the need for further research into the pathogenic mechanisms of enteric viruses and SARS-CoV-2.

Conclusions:

• Understanding the pathogenic mechanisms of enteric viruses is crucial for developing effective treatment strategies.
• The review provides a foundation for future research into enteric virus infections and their impact on public health.
• Further investigation into SARS-CoV-2's gastrointestinal effects is warranted given its pandemic relevance.