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Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

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Breath-Holding as a Stimulus to Assess Peripheral Oxygenation Flow Using Near-Infrared Spectroscopic Imaging.

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  • 1Optical Imaging Laboratory, Department of Biomedical Engineering, Florida International University, Miami, FL 33174, USA.

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Summary

Breath-holding (BH) can change blood flow and oxygenation in tissues. This study used BH to assess peripheral vascular response in diabetic foot ulcers (DFUs), finding it a viable method for DFU assessment.

Keywords:
breath-holdingdiabetic foot ulcersnear-infrared spectroscopic imagingoxygenation flow

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Area of Science:

  • Physiology
  • Medical Imaging
  • Vascular Biology

Background:

  • Mammalian breath-holding (BH) induces peripheral vasoconstriction, affecting blood and oxygen flow.
  • Diabetic foot ulcers (DFUs) are associated with impaired peripheral circulation.
  • Understanding vascular response in DFUs is crucial for effective treatment.

Purpose of the Study:

  • To investigate peripheral tissue oxygenation changes using a BH paradigm.
  • To assess the utility of BH as a stimulus in control and DFU subjects.
  • To evaluate the potential of BH for assessing vascular function in DFUs.

Main Methods:

  • Subjects (control and DFU) underwent a breath-hold paradigm including a 20-second BH.
  • Non-contact, spatio-temporal near-infrared spectroscopy (NIRS) was used for imaging.
  • Oxygenated flow changes were measured in wound and normal background tissues.

Main Results:

  • Oxygenated flow changes during BH were consistent across different skin colors.
  • Significant differences in oxygenation changes were observed between DFU wound sites and normal tissues.
  • Peripheral vasculature demonstrated a measurable response to oxygenation demand during BH.

Conclusions:

  • The breath-hold paradigm effectively induces peripheral tissue oxygenation changes.
  • NIRS imaging during BH can differentiate vascular responses in DFU subjects.
  • BH is a promising, non-contact method for assessing peripheral vascular function in DFUs.