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Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Modified-Release Drug Delivery Systems: Site-Targeted

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

Drug Delivery Systems: Different Types

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...

Modified-Release Drug Delivery Systems: Overview

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...

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Related Experiment Video

Updated: Jun 16, 2026

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Published on: January 15, 2018

Nanoparticle-Based Drug Delivery for Vascular Applications.

Atanu Naskar¹, Sreenivasulu Kilari¹, Gaurav Baranwal¹

¹Vascular and Interventional Radiology Translational Laboratory, Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.

Bioengineering (Basel, Switzerland)

|January 8, 2025

Summary

This review explores nanoparticle (NP) drug delivery systems for blood vessel treatments. It covers NP types, behaviors in blood, and targeting strategies for improved therapies.

Keywords:

biomedical applications drug delivery endothelium nanoparticle vascular applications

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Last Updated: Jun 16, 2026

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

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Published on: January 15, 2018

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Area of Science:

Biomedical Engineering
Materials Science
Pharmacology

Background:

Nanoparticle (NP)-based drug delivery systems leverage nanomaterials' properties for advanced therapies.
Various NP types, including lipid, PLGA, inorganic, carbon, 2D, and biomimetic NPs, are utilized as drug carriers.

Purpose of the Study:

To review customized NPs for intravascular drug delivery.
To discuss nanoparticle behavior within blood vessels (margination, adhesion, endothelium uptake).
To examine nanomaterial compatibility and cell surface protein targeting for effective vascular drug delivery.

Main Methods:

Comprehensive literature review of NP-based vascular drug delivery systems.
Analysis of nanoparticle physicochemical properties and interactions within the vasculature.
Evaluation of targeting strategies involving cell surface protein conjugation.

Main Results:

Detailed overview of diverse NP types suitable for intravascular administration.
Characterization of NP behaviors, including margination, adhesion, and uptake by endothelial cells.
Identification of key cell surface protein targets for enhanced drug delivery precision.

Conclusions:

Nanoparticle design and understanding their vascular behavior are crucial for effective drug delivery.
Targeted delivery via protein conjugation offers significant potential for vascular therapies.
Addressing limitations and challenges is vital for translating NP-based vascular drug delivery to clinical practice.