Chitosan-Based Multifunctional Biomaterials as Active Agents or Delivery Systems for Antibacterial Therapy

Area of Science:

• Biomaterials Science
• Antimicrobial Research
• Drug Delivery

Background:

• Antibiotic resistance is a growing global health threat due to widespread antibiotic misuse.
• There is an urgent need for novel therapeutic strategies beyond conventional antibiotics.
• Chitosan and its derivatives are emerging as promising alternatives owing to their inherent antibacterial properties.

Purpose of the Study:

• To review the biological properties of chitosan and its derivatives.
• To track the clinical applications of chitosan-based materials.
• To identify challenges and propose solutions for advancing chitosan in therapy.

Main Methods:

• Literature review of recent studies on chitosan and its derivatives.
• Analysis of biological activities, including antibacterial mechanisms.
• Examination of clinical trial data and case studies.

Main Results:

• Chitosan exhibits significant antibacterial activity against a range of pathogens.
• Derivatives enhance biocompatibility, biodegradability, and efficacy.
• Clinical applications span wound healing, drug delivery, and infection control.

Conclusions:

• Chitosan and its derivatives represent a viable alternative to antibiotics.
• Further research is needed to optimize formulations and address delivery challenges.
• Standardization and clinical validation are crucial for widespread adoption.