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Updates on Inflammatory Molecular Pathways Mediated by ADAM17 in Autoimmunity

Margherita Sisto1, Sabrina Lisi1

  • 1Department of Translational Biomedicine and Neuroscience (DiBraiN), Section of Human Anatomy and Histology, University of Bari "Aldo Moro", Piazza Giulio Cesare 1, I-70124 Bari, Italy.

Cells
|January 8, 2025
PubMed

Insights

ADAM17, a protease, regulates key signaling pathways involved in immunity and disease. This review clarifies its complex roles in autoimmune pathologies and identifies knowledge gaps for future research.

Area of Science:

  • Biochemistry
  • Immunology
  • Molecular Biology

Background:

  • ADAM17 (a disintegrin and metalloproteinase) is a transmembrane protease.
  • It regulates signaling pathways by shedding protein ectodomains.
  • ADAM17 plays roles in tumor progression and physiological processes.

Purpose of the Study:

  • To summarize recent findings on ADAM17's regulatory activities.
  • To focus on ADAM17's role in autoimmune diseases.
  • To clarify complex mechanisms and identify molecular gaps.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of data on ADAM17 substrates and signaling pathways.
  • Focus on studies related to autoimmunity.

Main Results:

  • ADAM17 is implicated in the shedding of growth factors, cytokines, receptors, and adhesion molecules.
  • ADAM17-dependent pathways are crucial in tumor development and autoimmune pathologies.
  • Recent research aims to elucidate ADAM17's diverse mechanisms and signaling cascades.

Conclusions:

  • ADAM17 is a key regulator in multiple biological processes, particularly autoimmunity.
  • Further research is needed to fully understand its complex signaling networks.
  • Clarifying molecular gaps can lead to new therapeutic strategies for autoimmune diseases.
Keywords:
ADAM17autoimmunityinflammation

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