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Current Advances and Future Directions of Pluripotent Stem Cells-Derived Engineered Heart Tissue for Treatment of

Xingyu He1, Angela Good1, Wael Kalou1

  • 1Department of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.

Cells
|January 8, 2025
PubMed

Insights

Engineered heart tissue (EHT) from human-induced pluripotent stem cells (hiPSCs) shows promise for treating myocardial infarction (MI) and heart failure by regenerating heart muscle. Innovations in bioengineering and AI address challenges for clinical translation.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • Cardiovascular diseases, particularly myocardial infarction (MI), are a leading cause of global mortality.
  • Current treatments for MI fail to regenerate lost heart muscle, increasing the risk of heart failure.
  • Engineered heart tissue (EHT) presents a potential solution for myocardial regeneration.

Purpose of the Study:

  • To review recent advancements in human-induced pluripotent stem cell (hiPSC)-derived EHTs.
  • To explore innovative materials and fabrication methods for EHT development.
  • To assess the therapeutic potential and translational challenges of hiPSC-EHTs.

Main Methods:

  • Review of literature on hiPSC-derived EHTs.
  • Focus on novel biomaterials and fabrication techniques (e.g., bioprinting, decellularization).
  • Analysis of preclinical and clinical study outcomes.

Main Results:

  • hiPSC-derived EHTs offer a promising avenue for cardiac repair.
  • Innovative materials and fabrication methods are improving EHT functionality.
  • Significant challenges remain in achieving functional integration, vascularization, and mechanical compatibility.

Conclusions:

  • hiPSC-EHTs hold significant therapeutic potential for MI and other cardiac conditions.
  • Genome editing, personalized medicine, and AI are key strategies to overcome translational barriers.
  • EHTs show broader applications in cardiovascular regenerative medicine, including drug screening.

Keywords:
AI integrationcardiovascular therapyengineered heart tissuegenome editinghuman pluripotent stem cellsmyocardial infarctionpersonalized medicinetissue engineering

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