Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

127
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
127
Bipolar Disorder01:30

Bipolar Disorder

52
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
52
Depression: Overview01:18

Depression: Overview

213
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
213
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

42
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
42
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

172
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
172
Long-term Depression01:03

Long-term Depression

2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex differences in animal models of complex disorders: Affective disorders, type 2 diabetes mellitus and essential hypertension.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Does Administration of Low-Dose Aspirin Enhance the Efficacy of Psychotropic Drugs in Patients with Bipolar Disorder, Schizophrenia, and Schizoaffective Disorder?

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Mitochondrial Insights into Lithium Response in Bipolar Disorder: A State-of-the-Art Review.

Neuropsychobiology·2025
Same author

The Role of FKBPs in Complex Disorders: Neuropsychiatric Diseases, Cancer, and Type 2 Diabetes Mellitus.

Cells·2024
Same author

The Effect of Global Warming on Complex Disorders (Mental Disorders, Primary Hypertension, and Type 2 Diabetes).

International journal of environmental research and public health·2022
Same author

Low-Dose Aspirin Augments the Anti-Inflammatory Effects of Low-Dose Lithium in Lipopolysaccharide-Treated Rats.

Pharmaceutics·2022

Related Experiment Video

Updated: Jun 3, 2025

Developing a Rat Model for Bipolar Disorder
04:44

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

201

Lithium, Inflammation and Neuroinflammation with Emphasis on Bipolar Disorder-A Narrative Review.

Odeya Damri1, Galila Agam1

  • 1Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Zlotowski Center for Neuroscience and Zelman Center-The School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

International Journal of Molecular Sciences
|January 8, 2025
PubMed
Summary

Lithium modulates immune responses, reducing inflammation and promoting cell survival across various studies. This review highlights its potential for treating bipolar disorder and other inflammatory conditions.

Keywords:
animal modelsclinical trialslithiumneuroinflammation

More Related Videos

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
08:33

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

9.7K
Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity
07:31

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity

Published on: August 23, 2022

3.1K

Related Experiment Videos

Last Updated: Jun 3, 2025

Developing a Rat Model for Bipolar Disorder
04:44

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

201
Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
08:33

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

9.7K
Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity
07:31

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity

Published on: August 23, 2022

3.1K

Area of Science:

  • Immunology
  • Neuroscience
  • Pharmacology

Background:

  • Lithium is a mood stabilizer for bipolar disorder (BD).
  • Its effects on immune function and inflammation are complex and not fully understood.
  • This review synthesizes current knowledge on lithium's immunomodulatory and anti-inflammatory actions.

Purpose of the Study:

  • To review lithium's impact on immune cells, inflammation, and cell survival.
  • To explore its mechanisms in vitro, animal models, and clinical studies, particularly in BD.
  • To assess lithium's therapeutic potential in inflammatory and neuroinflammatory conditions.

Main Methods:

  • Narrative review of in vitro, animal model, and clinical studies.
  • Analysis of lithium's effects on cytokine production (e.g., IL-1β, IL-10, TNF-α).
  • Examination of lithium's influence on immune cell function (monocytes, T-lymphocytes, macrophages) and neuronal survival.

Main Results:

  • High lithium concentrations protect cells and reduce IL-1β production.
  • Therapeutic lithium levels modulate both pro- and anti-inflammatory cytokines.
  • Lithium reduces neuroinflammation and alters cytokine profiles in BD patients.
  • Animal models show lithium alleviates inflammation and promotes selective macrophage death.

Conclusions:

  • Lithium exhibits diverse immunomodulatory and anti-inflammatory effects.
  • It promotes cell survival and reduces inflammation, with implications for BD and other conditions.
  • Further research is needed to fully elucidate lithium's therapeutic potential in immune regulation.