Related Experiment Video

Updated: Jun 3, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

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Exploring the Interplay of Gut Microbiota and Systemic Inflammation in Pediatric Obstructive Sleep Apnea Syndrome and

Chung-Guei Huang1,2, Wan-Ni Lin3,4, Li-Jen Hsin3,4

  • 1Department of Laboratory Medicine, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.

International Journal of Molecular Sciences
|January 8, 2025
PubMed

Insights

Pediatric obstructive sleep apnea syndrome (OSAS) is linked to gut bacteria and inflammation, affecting blood pressure (BP). Specific microbial and inflammatory profiles correlate with BP variations in children with OSAS.

Area of Science:

  • Pediatric cardiovascular health
  • Microbiome research
  • Sleep medicine

Background:

  • Obstructive sleep apnea syndrome (OSAS) is common in children and linked to high blood pressure (BP), increasing risks for hypertension and cardiovascular issues.
  • The influence of gut microbiota and systemic inflammation on pediatric BP in OSAS is not well understood, unlike in adults and animal models.

Purpose of the Study:

  • To investigate the associations between polysomnographic parameters, gut microbiota, systemic inflammation, and BP in children diagnosed with OSAS.
  • To identify specific microbial and inflammatory markers related to BP variations in pediatric OSAS.

Main Methods:

  • Cross-sectional study involving 60 children with OSAS.
  • Analysis of polysomnographic data, gut microbial profiles (including beta diversity and marker microbes), and systemic inflammation markers (e.g., interleukin-17, tumor necrosis factor-α).
  • Correlation analysis between microbial/inflammatory markers and BP levels.

Main Results:

  • Significant associations were found between specific gut microbial profiles and BP variations in children with OSAS.
  • Observed correlations between microbial profiles and altered systemic inflammation markers, including interleukin-17 and tumor necrosis factor-α.
  • The abundance of *Acinetobacter* was specifically linked to changes in inflammatory markers and BP.

Conclusions:

  • Gut microbiota and systemic inflammation play a significant role in pediatric cardiovascular health among children with OSAS.
  • Unique microbial and cytokine profiles are associated with different BP levels in these children.
  • Integrating gut microbiota management into cardiovascular risk strategies for pediatric OSAS is recommended, warranting further mechanistic research.

Keywords:
blood pressuregut microbiotainterleukin-17obstructive sleep apnea syndromesystemic inflammationtumor necrosis factor-α

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