Related Experiment Video
Updated: Jun 3, 2025
09:20
An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
Published on: May 4, 2021
3.5K
Exploring the Link Between Psoriasis and Adipose Tissue: One Amplifies the Other
Roberta Di Caprio1, Ersilia Nigro2,3, Eugenia Veronica Di Brizzi1
1Unit of Dermatology, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
International Journal of Molecular Sciences
|January 8, 2025
Summary
Psoriasis and obesity worsen each other through inflammation. Cytokines like IL-17 and TNF-α impact adipose tissue (AT) metabolism, while AT mediators amplify skin inflammation, revealing a mutual exacerbation cycle.
Area of Science:
- Immunology
- Metabolic Diseases
- Dermatology
Background:
- Psoriasis and obesity are distinct yet interconnected inflammatory conditions.
- Adipose tissue (AT) mediators and psoriasis-associated cytokines may influence each other's pathogenesis.
- Understanding this relationship is crucial for effective treatment strategies.
Purpose of the Study:
- To investigate the pathogenic role of psoriasis-signature cytokines on AT metabolism.
- To determine the role of AT-derived mediators in exacerbating skin inflammation.
Main Methods:
- Whole adipose tissue was treated with IL-17 and TNF-α to assess adipokine and inflammatory factor expression.
- Ex vivo skin organ cultures were used to evaluate the effects of inflamed AT mediators on skin inflammation.
Main Results:
- IL-17 and TNF-α demonstrated additive or synergistic effects on AT-derived mediators.
- Inflamed AT, stimulated by psoriasis cytokines, led to increased inflammatory mediators in skin organ cultures.
Conclusions:
- Psoriasis and obesity mutually amplify inflammatory processes.
- Targeting both skin inflammation and AT metabolism may offer more effective therapeutic strategies.
Related Concept Videos
01:24Obesity
372
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
372
01:24T Cell Types and Functions
946
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
946
01:02Hypodermis
4.0K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
4.0K
01:38Inflammation
52.5K
Overview
52.5K
01:20The JAK-STAT Signaling Pathway
8.7K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.7K
01:19Interactions Between Signaling Pathways
6.2K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.2K