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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

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Etiology-Dependent Microbiome Differences in Hepatocellular Carcinoma Development.

Nevena Todorovic^1,2, Serena Martinelli¹, Giulia Nannini¹

¹Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.

International Journal of Molecular Sciences

|January 8, 2025

Summary

The gut microbiota influences chronic liver diseases, including viral hepatitis and non-alcoholic fatty liver disease. Microbial imbalances contribute to liver damage, cirrhosis, and hepatocellular carcinoma (HCC) development.

Keywords:

cirrhosis fibrosis gut microbiota hepatocellular carcinoma oncobiome steatosis

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A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

Published on: August 7, 2020

Area of Science:

Microbiology and Hepatology
Gut-liver axis research
Oncovirome in cancer development

Background:

Chronic liver disease involves inflammation, damage, and regeneration, progressing to cirrhosis and hepatocellular carcinoma (HCC).
Gut microbiota plays a crucial role in health, and its dysbiosis is linked to various pathologies, including chronic liver diseases.
Intratumoural microbiota, or the 'oncobiome,' is increasingly recognized for its impact on HCC development and progression.

Purpose of the Study:

To review the influence of gut microbiota on viral hepatitis (Hepatitis B and C) progression.
To explore microbial dysbiosis in non-alcoholic fatty liver disease (NAFLD) and its silent progression.
To examine alcohol's impact on the liver and its interaction with microbiota, linking inflammation to cirrhosis and cancer.

Main Methods:

Literature review of existing research on microbiota and liver disease.
Analysis of studies focusing on viral hepatitis, NAFLD, and alcohol-related liver disease.
Exploration of the oncobiome's role in hepatocellular carcinoma (HCC) pathogenesis.

Main Results:

Gut microbiota significantly shapes the progression of liver disease in viral hepatitis.
Microbial dysbiosis is a key factor in the silent and dangerous progression of NAFLD.
Alcohol-induced liver injury involves complex interactions with the gut microbiota, contributing to cirrhosis and HCC.

Conclusions:

The gut microbiota is a critical determinant in the pathogenesis of various chronic liver diseases.
Understanding the oncobiome offers new insights into hepatocellular carcinoma development.
Targeting microbial dysbiosis presents potential therapeutic strategies for liver disease and HCC prevention.