Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

4.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

130
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
130

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical evaluation of a computer-assisted decision support and documentation system for the primary care of polytrauma patients.

Frontiers in digital health·2026
Same author

Effect of green mediterranean diet on serum folate and its interaction with genetic variation in folate metabolism: The DIRECT PLUS 18-month dietary randomized controlled trial.

Clinical nutrition (Edinburgh, Scotland)·2026
Same author

Lifestyle-Induced Visceral Fat Loss as a Key Target for Durable Cardiometabolic Health: MRI-Assessed 5- and 10-Year Follow-Up After 2 Clinical Trials.

Circulation·2026
Same author

Development and Analytical Validation of a Multiplex LC-MRM-MS-Based Reference Measurement Procedure for Apolipoprotein A-I and Btotal Quantification in Serum.

Clinical chemistry·2026
Same author

Endothelial dysfunction and metabolic biomarkers in post-COVID-19 syndrome.

Scientific reports·2026
Same author

Evaluation of Intravenous Administration of Anti-Infective Agents and Documentation Quality in Orthopedics and Trauma Surgery: A Quantitative Study on Discrepancies Between Physician Prescriptions and Nursing Records.

Antibiotics (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jun 3, 2025

Shotgun Lipidomics of Rodent Tissues
11:46

Shotgun Lipidomics of Rodent Tissues

Published on: November 18, 2022

2.0K

Severity-Dependent Long-Term Post-Traumatic Changes in the Circulating Oxylipin Profile.

Madlen Reinicke1, Leyu Zheng2, Moujie Rang2

  • 1Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, 04103 Leipzig, Germany.

International Journal of Molecular Sciences
|January 8, 2025
PubMed
Summary
This summary is machine-generated.

Trauma significantly alters circulating oxylipins, impacting polyunsaturated fatty acids (PUFAs). Specific oxylipins decrease long-term post-injury, correlating with severity, while others transiently increase, indicating diagnostic potential.

Keywords:
arachidonic acidinjuryoxylipinpolytraumapolyunsaturated fatty acid

More Related Videos

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.2K
Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome
06:06

Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome

Published on: October 26, 2018

9.8K

Related Experiment Videos

Last Updated: Jun 3, 2025

Shotgun Lipidomics of Rodent Tissues
11:46

Shotgun Lipidomics of Rodent Tissues

Published on: November 18, 2022

2.0K
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.2K
Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome
06:06

Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome

Published on: October 26, 2018

9.8K

Area of Science:

  • Biochemistry
  • Trauma Medicine
  • Metabolomics

Background:

  • Trauma disrupts cell membranes, releasing polyunsaturated fatty acids (PUFAs).
  • These PUFAs degrade into oxylipins, some with biological activity.
  • The impact of trauma on the circulating oxylipidome is not fully understood.

Purpose of the Study:

  • To screen for circulating PUFAs and oxylipins in trauma patients.
  • To analyze the diagnostic potential of these molecules.
  • To understand the temporal changes in the oxylipidome after injury.

Main Methods:

  • Screening of circulating PUFAs and oxylipins in trauma patients (n=34) and controls (n=25).
  • Follow-up of patients from 1 to 240 hours post-injury across different severity levels.
  • Analysis of oxylipin levels and correlation with clinical parameters and inflammatory markers.

Main Results:

  • Injury led to long-term decreases in specific hydroxyoctadecadienoic acids and dihydroxyeicosatetraenoic acids compared to controls.
  • These decreased oxylipins inversely correlated with injury severity and inflammatory markers.
  • Some oxylipins showed transient increases immediately post-injury, correlating with adverse clinical parameters.

Conclusions:

  • The circulating oxylipidome is significantly altered by trauma.
  • Specific oxylipins demonstrate injury-dependent alterations throughout the post-traumatic course.
  • These findings suggest potential diagnostic utility for oxylipins in trauma management.