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Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
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The RAGE Pathway in Skin Pathology Development: A Comprehensive Review of Its Role and Therapeutic Potential

Marcin Radziszewski1,2, Ryszard Galus1, Krzysztof Łuszczyński1,3

  • 1Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warsaw, Poland.

International Journal of Molecular Sciences
|January 8, 2025
PubMed

Insights

The receptor for advanced glycation end-products (RAGE) plays a key role in skin diseases by driving inflammation and tissue remodeling. Targeting RAGE pathways offers potential new treatments for conditions like psoriasis and atopic dermatitis.

Area of Science:

  • Dermatology
  • Immunology
  • Molecular Biology

Background:

  • The receptor for advanced glycation end-products (RAGE) is an immunoglobulin superfamily member involved in cellular responses.
  • RAGE activation triggers signaling pathways linked to inflammation, oxidative stress, and proliferation.
  • Its role in skin pathologies is less understood compared to its involvement in diabetes and cancer.

Purpose of the Study:

  • To review the current understanding of RAGE's involvement in skin disease pathophysiology.
  • To focus on RAGE's roles in inflammatory signaling, tissue remodeling, and skin cancer progression in dermatological conditions.
  • To examine RAGE-modulating treatments for skin diseases.

Main Methods:

  • Literature review synthesizing existing research on RAGE in skin diseases.
  • Analysis of RAGE's contribution to the pathogenesis of specific conditions like psoriasis, atopic dermatitis, and lichen planus.
  • Evaluation of therapeutic strategies targeting RAGE in dermatological contexts.

Main Results:

  • RAGE is implicated in the pathogenesis of various skin diseases, including psoriasis, atopic dermatitis, and lichen planus.
  • RAGE activation contributes to inflammatory signaling, abnormal tissue remodeling, and skin cancer progression.
  • Several RAGE-modulating treatments have shown potential in dermatological research.

Conclusions:

  • RAGE is a significant factor in the pathophysiology of diverse skin conditions.
  • Understanding RAGE-mediated pathways is crucial for developing targeted dermatological therapies.
  • Further research into skin-specific RAGE signaling may reveal novel therapeutic opportunities.
Keywords:
RAGEfibrosisinflammationskin diseasesskin neoplasms

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