Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

35.8K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.8K
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

6.4K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
6.4K
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

2.9K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
2.9K
Proteomics01:33

Proteomics

7.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association Between Maternal Gestational Diabetes, Cord Blood DNA Methylation, and Offspring Neurodevelopment.

International journal of molecular sciences·2026
Same author

Rare genetic variant risks in patients with sepsis-associated acute respiratory distress syndrome.

Respiratory research·2026
Same author

Identifying sepsis susceptibility genes in post-surgical patients using an artificial intelligence approach.

Frontiers in medicine·2025
Same author

Genome-wide association study of susceptibility to acute respiratory distress syndrome.

EBioMedicine·2025
Same author

Genetic variability of Shiga toxin-producing <i>Escherichia coli</i> strains isolated from Paraguayan cattle.

Microbiology spectrum·2025
Same author

IEIVariantFilter: a bioinformatics tool to speed up genetic diagnosis of inborn errors of immunity patients.

NAR genomics and bioinformatics·2025

Related Experiment Video

Updated: Jun 3, 2025

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.4K

Defining the Differential Corticosteroid Response Basis from Multiple Omics Approaches.

Melody Ramirez-Falcon1,2, Eva Suarez-Pajes1, Carlos Flores1,2,3,4

  • 1Research Unit, Hospital Universitario Ntra. Sra. de Candelaria, Instituto de Investigación Sanitaria de Canarias, 38010 Santa Cruz de Tenerife, Spain.

International Journal of Molecular Sciences
|January 8, 2025
PubMed
Summary

Corticosteroids are widely used but show variable patient responses. Omics approaches are revealing genetic factors influencing treatment efficacy and side effects, addressing critical knowledge gaps.

Keywords:
corticosteroidsepigenomicsgenomicsglucocorticoidsmetabolomicsproteomicstranscriptomics

More Related Videos

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.1K
A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
09:35

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

17.8K

Related Experiment Videos

Last Updated: Jun 3, 2025

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.4K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.1K
A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
09:35

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

17.8K

Area of Science:

  • Pharmacogenomics
  • Molecular Medicine
  • Genetics

Background:

  • Corticosteroids are essential treatments for numerous diseases like asthma and leukemia.
  • Interindividual variability in patient response and side effects remains a significant clinical challenge.
  • The underlying genetic basis for these variations is not fully understood.

Purpose of the Study:

  • To review recent literature on factors influencing corticosteroid response.
  • To focus on the role of omics approaches in understanding genetic variability.
  • To identify knowledge gaps requiring further research in corticosteroid treatment.

Main Methods:

  • Comprehensive literature review of studies on corticosteroid response.
  • Emphasis on genomic, transcriptomic, and other omics-based investigations.
  • Analysis of data related to interindividual variability in treatment efficacy and adverse effects.

Main Results:

  • Omics technologies are beginning to elucidate genetic factors affecting corticosteroid efficacy.
  • Variability in patient response is linked to genetic predispositions.
  • Significant knowledge gaps persist regarding the precise genetic influences.

Conclusions:

  • Understanding genetic factors is crucial for personalized corticosteroid therapy.
  • Further omics research is urgently needed to optimize treatment strategies.
  • Addressing interindividual variability will improve patient outcomes and reduce side effects.