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Updated: Jun 3, 2025
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Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
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Heteroleptic Coumarin-Based Silver(I) Complexes: Possible New Antimicrobial Agents.
Erika Mooney1,2, Brendan Twamley3, Gordon Cooke1,2
1School of Chemical and BioPharmaceutical Sciences, Technological University Dublin, TU Dublin, Tallaght Campus, D24 FKT9 Dublin, Ireland.
Molecules (Basel, Switzerland)
|January 8, 2025
Summary
Synthesizing novel coumarin-based silver(I) complexes with enhanced solubility improved photostability but did not increase antimicrobial efficacy against common pathogens like E. coli and P. aeruginosa.
Area of Science:
- Inorganic Chemistry
- Medicinal Chemistry
- Materials Science
Background:
- Silver(I) complexes are explored for antimicrobial properties.
- Coumarin derivatives offer tunable properties for complexation.
- Improving solubility and stability of metal complexes is crucial for applications.
Purpose of the Study:
- To synthesize and characterize novel heteroleptic coumarin-based silver(I) complexes.
- To investigate the impact of adduct ligands (triphenylphosphine and N-heterocyclic carbene) on solubility, photostability, and structure.
- To evaluate the antimicrobial activity of these novel silver(I) complexes against pathogenic bacteria.
Main Methods:
- Synthesis of silver(I) complexes with coumarin, oxyacetate, and adduct ligands.
- Characterization using IR, NMR spectroscopy, elemental analysis, and X-ray crystallography.
- Antimicrobial activity assessment via Kirby Bauer and broth microdilution assays against Pseudomonas aeruginosa, Escherichia coli, and MRSA.
Main Results:
- Successfully synthesized heteroleptic coumarin-based silver(I) complexes with triphenylphosphine and N-heterocyclic carbene (NHC) adducts.
- Triphenylphosphine adducts showed well-defined structures with improved solubility and photostability.
- The NHC adduct likely formed complex aggregates.
- Increased solubility did not enhance, and in some cases reduced, antimicrobial activity against E. coli and P. aeruginosa, while activity against MRSA was retained.
Conclusions:
- Enhanced solubility and photostability of coumarin-silver(I) complexes were achieved.
- Solubility improvements did not correlate with increased antimicrobial efficacy.
- The specific structure and aggregation state may influence antimicrobial activity.
- Further research is needed to optimize silver(I) complexes for targeted antimicrobial applications.
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