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Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Coagulation01:06

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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
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Sample Preparation for Analysis: Overview01:21

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Sample preparation is an essential step in the analytical process. It involves preparing a sample so that it can be analyzed accurately. The goal is to extract the analyte, the substance you want to measure, from the sample while removing any components that may interfere with the analysis. Sample preparation techniques vary depending on the physical state of the sample.
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Related Experiment Video

Updated: Jun 3, 2025

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Study on Preparation Process of Anticoagulant BAY2433334.

Yanqun Zeng1, Guodong Cen1, Guanglin Zhou1

  • 1Chengdu Shibeikang Biomedical Technlogy Co., Ltd., 26-1-2, No.2 Tianyu Road, Chendu Gaoxin West District, Chengdu 611700, China.

Molecules (Basel, Switzerland)
|January 8, 2025
PubMed
Summary

A novel industrial synthesis for BAY2433334 was developed, bypassing existing patents. This efficient process yields high-purity BAY2433334 with minimal impurities, eliminating the need for chiral resolution and reducing costs.

Keywords:
(2R)-2-aminobutyric acidBAY2433334N-alkylation/O-alkylation ratioee valuep-toluenesulfonyl chloride

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Area of Science:

  • Chemical synthesis
  • Process chemistry
  • Pharmaceutical manufacturing

Background:

  • BAY2433334 is a significant pharmaceutical compound.
  • Existing synthesis routes for BAY2433334 are subject to patent limitations.
  • Industrial-scale production requires cost-effective and efficient methods.

Purpose of the Study:

  • To develop a new, patent-unencumbered process for industrial BAY2433334 production.
  • To establish a cost-effective and scalable synthesis route.
  • To achieve high product purity and yield.

Main Methods:

  • The synthesis starts from (2R)-2-aminobutyric acid.
  • Key reactions include esterification, diazotization, condensation, deacetylation, activation, and Mitsunobu reactions.
  • The process is designed for operational simplicity and uses readily available raw materials.

Main Results:

  • A new industrial process route for BAY2433334 has been successfully developed.
  • The process yields high-purity BAY2433334 with a high N-alkylated product/O-alkylated product ratio (>35-45:1).
  • The enantiomeric excess (ee) value exceeds 99%, obviating the need for chiral resolution and significantly reducing costs.

Conclusions:

  • The developed process offers a viable, patent-free alternative for industrial BAY2433334 production.
  • This method is simple, cost-effective, and yields a high-quality product.
  • The high enantiomeric purity achieved simplifies downstream processing and reduces overall manufacturing expenses.