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Berbamine Promotes the Repair of Lower Limb Muscle Damage in Chronic Limb-Threatening Ischemia by Inhibiting Local

Lei Zheng1, Biao Zhao1, Zhenxi Zhang1

  • 1Department of Vascular Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Zhongshan Road 321, Nanjing 210008, China.

Pharmaceuticals (Basel, Switzerland)
|January 8, 2025
PubMed

Insights

Berbamine (BBM) shows potential in treating Chronic Limb-Threatening Ischemia (CLTI). This study found BBM can restore muscle function and repair tissue damage by reducing inflammation and promoting blood vessel growth.

Area of Science:

  • Vascular Biology
  • Regenerative Medicine
  • Pharmacology

Background:

  • Chronic Limb-Threatening Ischemia (CLTI) is a severe vascular condition causing pain, ulcers, and gangrene.
  • CLTI arises from vascular lesions and can be life-threatening.

Purpose of the Study:

  • To investigate the protective and reparative effects of Berbamine (BBM) on ischemic lower limb muscle tissue.
  • To evaluate BBM's therapeutic potential for CLTI.

Main Methods:

  • A mouse hindlimb ischemia (HLI) model was utilized.
  • 36 C57BL6 mice were allocated into sham, HLI, and HLI+BBM groups.

Main Results:

  • BBM treatment restored motor function and improved muscle tissue pathology in HLI mice.
  • BBM inhibited NF-κB nuclear translocation, reducing inflammation and muscle cell apoptosis.
  • BBM suppressed M1 macrophage polarization and promoted angiogenesis.

Conclusions:

  • Berbamine demonstrates protective effects against ischemic muscle damage in the lower limbs.
  • BBM may offer a novel therapeutic strategy for treating CLTI.
  • Further research into BBM for CLTI is warranted.

Keywords:
apoptosisberbamineinflammationlimb ischemianuclear factor kappa-B

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