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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Non-[18F]FDG PET-Radiopharmaceuticals in Oncology

Antonia Dimitrakopoulou-Strauss1, Leyun Pan1, Christos Sachpekidis1

  • 1Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

Pharmaceuticals (Basel, Switzerland)
|January 8, 2025
PubMed

Insights

Advancements in molecular imaging, particularly novel PET radiopharmaceuticals beyond [18F]FDG, are enhancing cancer diagnostics and personalized therapies by visualizing specific molecular targets and pathways.

Area of Science:

  • Molecular imaging
  • Radiopharmaceutical development
  • Oncology

Background:

  • Technological progress in PET-CT scanners (digital detectors, extended field of view) increases sensitivity.
  • Development of specific radiopharmaceuticals is vital for personalized cancer treatment.
  • Novel peptides enable visualization of diverse targets like PD-1/PD-L1, chemokines, HER, T-cells, and the tumor microenvironment (e.g., FAP imaging).

Purpose of the Study:

  • To review recent advancements in non-[18F]FDG PET radiopharmaceuticals for oncology.
  • To discuss their current clinical applications.
  • To explore future directions in the field.

Main Methods:

  • Review of recent scientific literature on novel PET radiopharmaceuticals.
  • Analysis of technological improvements in PET-CT imaging.
  • Compilation of data on clinical applications and theranostic potential.

Main Results:

  • Significant progress in developing targeted radiotracers beyond [18F]FDG.
  • Demonstrated utility in visualizing specific molecular pathways and cellular targets in cancer.
  • Emerging theranostic applications for improved patient management.

Conclusions:

  • Non-[18F]FDG PET radiopharmaceuticals represent a significant leap in molecular imaging for oncology.
  • These tracers offer precise visualization for personalized diagnostics and therapeutic strategies.
  • Continued research promises further expansion of their clinical utility and theranostic capabilities.
Keywords:
PET radiopharmaceuticalsimmuno-PEToncologytotal-body PET

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