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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Lysogenic Cycle of Bacteriophages00:43

Lysogenic Cycle of Bacteriophages

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In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
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Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
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Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

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Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
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Transmission-based Precautions I: Contact, Enteric, and Droplets01:17

Transmission-based Precautions I: Contact, Enteric, and Droplets

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Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
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Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
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Related Experiment Video

Updated: Jun 3, 2025

Author Spotlight: Development of an Enhanced Protocol for Rapid and Accurate Isolation of Campylobacter from Food Products
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Author Spotlight: Development of an Enhanced Protocol for Rapid and Accurate Isolation of Campylobacter from Food Products

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Campylobacter jejuni/coli Infection: Is It Still a Concern?

Piero Veronese1, Icilio Dodi1

  • 1Pediatric Infectious Disease Unit, Barilla Children's Hospital of Parma, 43126 Parma, Italy.

Microorganisms
|January 8, 2025
PubMed
Summary

Campylobacteriosis, a common foodborne illness, is spread through contaminated food and water. Antibiotic resistance in Campylobacter is a major public health concern, with current vaccines lacking efficacy.

Keywords:
Campylobacterantibiotic resistancefoodborne illnesspediatric population

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Campylobacteriosis is a significant global cause of infectious diarrhea and foodborne illness.
  • Transmission occurs via contaminated food (undercooked meat), water, or animal contact, with poultry as the primary reservoir.
  • Infections present with gastrointestinal or extraintestinal symptoms, and potential late complications include reactive arthritis and Guillain-Barré syndrome.

Purpose of the Study:

  • To review the epidemiology, clinical manifestations, and public health challenges of Campylobacteriosis.
  • To highlight the growing issue of antibiotic resistance in Campylobacter infections.
  • To assess the current status of vaccine development for reducing poultry colonization.

Main Methods:

  • Literature review of epidemiological data and clinical case studies.
  • Analysis of public health reports on antibiotic resistance trends.
  • Evaluation of vaccine research and development for Campylobacter control.

Main Results:

  • The 0-4 age group shows the highest incidence of campylobacteriosis in pediatric populations.
  • Antimicrobial therapy is recommended for severe intestinal infections, with treatment decisions influenced by host factors.
  • Increasing resistance to fluoroquinolones and macrolides poses a significant public health threat.
  • Existing vaccines for poultry have not demonstrated sufficient efficacy for widespread use.

Conclusions:

  • Campylobacteriosis remains a critical public health issue, necessitating strategies to combat antibiotic resistance.
  • Effective vaccines are needed to reduce poultry colonization and subsequent human transmission.
  • Further research into alternative therapeutic approaches and preventative measures is essential.