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Precipitation Polymerization-Based Molecularly Imprinted Polymers: A Novel Approach for Transdermal Curcumin Delivery
Muhammad Cholid Djunaidi1, Viona Resda Putri1, Nesti Dwi Maharani1
1Department of Chemistry, Faculty of Science and Mathematics, Diponegoro University, Jl. Prof. Soedharto SH, Tembalang, Semarang 50275, Indonesia.
Polymers
|January 8, 2025
Summary
This study developed a molecularly imprinted polymer (MIP) for controlled transdermal curcumin delivery. The MIP demonstrated enhanced curcumin adsorption and a reduced release rate, making it a promising candidate for drug delivery applications.
Area of Science:
- Polymer Chemistry
- Materials Science
- Pharmaceutical Sciences
Background:
- Curcumin, a natural compound, has therapeutic potential but faces bioavailability challenges.
- Transdermal drug delivery offers a non-invasive route for systemic drug administration.
- Developing suitable carriers is crucial for effective transdermal delivery of hydrophobic drugs like curcumin.
Purpose of the Study:
- To synthesize and characterize a molecularly imprinted polymer (MIP) for curcumin transdermal delivery.
- To evaluate the adsorption capacity and release kinetics of the MIP for curcumin.
- To assess the potential of the MIP as a controlled release system for transdermal curcumin.
Main Methods:
- Precipitation polymerization using methacrylic acid and ethylene glycol dimethacrylate.
- Morphological and chemical characterization using SEM-EDX and FTIR spectroscopy.
- Adsorption studies following Langmuir isotherm and release kinetics studies following Higuchi model.
Main Results:
- The synthesized MIP exhibited a uniform granular morphology.
- MIP showed a higher adsorption capacity (4.239 mg/g) compared to the non-imprinted polymer (NIP, 3.219 mg/g), with an imprinting efficiency of 1.317.
- MIP demonstrated a reduced curcumin release rate (41.26% after 8 h) compared to NIP (51.50%), indicating controlled diffusion.
Conclusions:
- The developed MIP is suitable for curcumin transdermal delivery.
- The imprinting process effectively modified the polymer matrix for controlled drug release.
- MIP shows potential as a carrier for controlled transdermal delivery of curcumin.
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