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Reported Adverse Events Following SARS-CoV-2 Vaccinations in the Canadian Province of Alberta and Associated Risk Factors: A Retrospective Cohort Study

  • 0School of Public Health, University of Saskatchewan, 104 Clinic Place, Saskatoon, SK S7N2Z4, Canada.
Vaccines +

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January 8, 2025

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January 8, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Adverse events following immunization (AEFI) were rare in Albertans vaccinated against COVID-19, with most events mild and occurring after the first dose. Females and those with comorbidities faced higher risks, underscoring the need for ongoing vaccine safety monitoring.

Area Of Science

  • Epidemiology
  • Vaccinology
  • Public Health

Background

  • Coronavirus disease 2019 (COVID-19) vaccines are critical public health tools.
  • Post-marketing surveillance is essential for ensuring vaccine safety and effectiveness.
  • Understanding adverse events following immunization (AEFI) informs vaccination policies.

Purpose Of The Study

  • To determine the incidence of reported AEFIs in Albertans vaccinated against COVID-19.
  • To identify risk factors associated with AEFIs in this population.
  • To provide data for ongoing COVID-19 vaccine safety monitoring.

Main Methods

  • Retrospective cohort study of Albertans aged 5+ vaccinated between December 2020 and April 2022.
  • Analysis of reported AEFIs and associated demographic and clinical factors.
  • Calculation of AEFI incidence rates per 100,000 doses for mRNA vaccines.

Main Results

  • 3,527,106 individuals included; 2541 (72.0 per 100,000) reported AEFIs.
  • Most AEFIs occurred after the first dose and within one week post-vaccination.
  • Females, individuals aged 35-54, and those with comorbidities showed higher AEFI incidence; allergic events were most common.

Conclusions

  • COVID-19 vaccination in Alberta was associated with a low incidence of serious adverse events.
  • Female sex, comorbidities, and vaccine type were significant risk factors for AEFIs.
  • Further research is needed to identify unknown risk factors for AEFIs.

Keywords:

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