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Thymidine Analogue Mutations with M184V Significantly Decrease Phenotypic Susceptibility of HIV-1 Subtype C Reverse

Hyeonah Byun1, Maria Antonia Papathanasopoulos1, Kim Steegen2,3

  • 1HIV Pathogenesis Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.

Viruses
|January 8, 2025
PubMed
Summary

Islatravir shows effectiveness against common HIV-1 subtype C nucleoside reverse transcriptase inhibitor resistance mutations. However, combinations involving M184V with thymidine analogue mutations may reduce susceptibility, impacting treatment strategies.

Keywords:
HIVNRTIantiretroviral therapy (ART)antiviral drugsdrug resistanceislatravir (ISL)phenotypicsubtype C

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