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Updated: Jun 3, 2025

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
Fatty acid transporters as potential diagnostic markers for colorectal cancer
Wojciech Michał Jankowski1, Jakub Fichna1, Aleksandra Tarasiuk1
1Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
Abstract:
Colorectal cancer (RJG) is one of the most frequently diagnosed malignant neoplasms: approximately 1.9 million new cases are reported annually. Notwithstanding the advent of techniques for the early detection of RJG and the introduction of novel therapeutic modalities, this disease remains the second leading cause of cancer-related mortality. The results of recent studies highlight the role of fatty acid transporters, including fatty acid translocase/cluster of differentiation 36 (FAT/CD36), fatty acid transport proteins (FATPs), and fatty acid-binding proteins (FABPs), in the pathogenesis of RJG. Changes in serum concentrations and in expression levels in tumor tissue may serve as promising biomarkers for the early diagnosis of the disease and/or the monitoring of its progression and the efficacy of its treatment. Moreover, the fatty acid carriers present a promising avenue for the development of efficacious therapies against RJG.
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