Cobalt(II)-Catalyzed Selective C2-H Heck Reaction of Native (N-H) Indoles Enabled by Salicylaldehyde Ligand
Jia-Wei Li1, Shuai Shi2, Xiao-Hong Chen2
1Institute of Medicinal Development and Application for Aquatic Disease Control, Zhoukou Key Laboratory of Small Molecule Drug Development and Application, School of Chemistry and Chemical Engineering, Zhoukou Normal University, Zhoukou 466001, P. R. China.
Abstract:
Direct functionalization of native (N-H) indoles via C-H activation remains a challenge. Herein, we report a salicylaldehyde-promoted cobalt-catalyzed selective C2-H Heck reaction of native (N-H) indoles with both active and unactivated olefins in the presence of free N-H bonds. A series of structurally diverse C2-alkenylated native (N-H) indoles including natural product and drug derivatives were prepared directly and effectively without additional preprotection and deprotection procedures.
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