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Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
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Anticoagulant Drugs: Low-Molecular-Weight Heparins

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Coagulation

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Related Experiment Video

Updated: Jun 3, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Bullous pemphigoid and hypercoagulability: a review.

Bingjie Zhang¹, Nan Yang², Li Li¹

¹Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China.

Expert Review of Clinical Immunology

|January 8, 2025

Summary

Bullous pemphigoid (BP) is an autoimmune disease linked to increased clotting risk. Monitoring coagulation markers like D-dimer is vital for managing BP patients with thrombotic events.

Keywords:

Bullous pemphigoid coagulation parameter hypercoagulability thrombo-prophylaxis thrombosis

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Granulocyte-dependent Autoantibody-induced Skin Blistering

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Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

Area of Science:

Dermatology
Hematology
Immunology

Background:

Bullous pemphigoid (BP) is an autoimmune blistering disease.
BP is associated with a high incidence of thrombotic events, indicating a hypercoagulable state.

Purpose of the Study:

To review the interplay between coagulation and immune-inflammatory responses in BP.
To highlight characteristic coagulation parameter changes in BP patients.

Main Methods:

Literature review up to August 2024.
Selective search in the PubMed database.

Main Results:

The hypercoagulable state and BP have a mutually reinforcing effect.
Key coagulation markers to monitor include D-dimer, fibrinogen, and fibrin degradation products (FDP).

Conclusions:

Close monitoring of coagulation markers is crucial for BP patients.
Targeting shared pathways in treatment may benefit patients with both BP and hypercoagulability.