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Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum Clove and Cuminun cyminum Cumin on C57BL6/j Mice Fed High-Fat Diet
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Enhance Anti-obesity Effect of Natural Compounds through Carrier Mediation

Mingyue Peng1, Hao Wang1, Zhenjing Liu1

  • 1Department of Biopharmaceutical Science, Shanghai Ocean University, Hucheng Ring Road, Shanghai, 201306, China.

Current Medicinal Chemistry
|January 8, 2025
PubMed

Insights

Emerging obesity treatments leverage natural compounds delivered via advanced carriers for targeted therapy. This review explores their potential to overcome limitations of current anti-obesity drugs.

Area of Science:

  • Pharmacology and Materials Science
  • Biomedical Engineering
  • Public Health

Background:

  • Obesity is a global health crisis with severe comorbidities.
  • Current anti-obesity medications have limitations including bioavailability, specificity, and toxicity.
  • There is a critical need for novel and safer obesity treatment strategies.

Purpose of the Study:

  • To review the current status and challenges of natural compounds in obesity treatment.
  • To summarize the advanced functions and prospects of carrier delivery systems for natural obesity treatments.
  • To explore the application of these novel strategies in preclinical and clinical research.

Main Methods:

  • Systematic review of existing literature on natural compounds and drug delivery systems for obesity.
  • Analysis of emerging obesity treatment strategies integrating materials science and natural product chemistry.
  • Evaluation of preclinical and clinical research data on carrier-mediated delivery of natural anti-obesity agents.

Main Results:

  • Natural compounds show promise as alternatives to conventional anti-obesity drugs.
  • Carrier delivery systems enhance the targeted delivery and efficacy of natural ingredients.
  • Emerging strategies offer potential solutions to overcome limitations of current obesity pharmacotherapies.

Conclusions:

  • Carrier-mediated delivery of natural compounds represents a promising frontier in obesity treatment.
  • Further research is needed to address challenges in targeted delivery and clinical translation.
  • Multidisciplinary approaches are essential for developing next-generation anti-obesity therapies.
Keywords:
Natural compoundsanti-obesitycardiovascular diseasecarrier deliveryfat thermogenesis.intestinal flora

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