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Updated: Jun 3, 2025

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
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Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

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Interaction between microRNA and KRAS in Glioblastoma

Ozal Beylerli1, Elmar Musaev2, Gervith Reyes Soto3

  • 1Central Research Laboratory, Bashkir State Medical University, Ufa, Republic of Bashkortostan, 3 Lenin Street, 450008, Russia.

Current Medicinal Chemistry
|January 8, 2025
PubMed

Insights

This study explores the intricate relationship between Kirsten rat sarcoma virus (KRAS) and microRNAs (miRNAs) in glioblastoma (GBM). Understanding this connection may lead to novel therapeutic strategies for this aggressive brain cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Glioblastoma (GBM) is an aggressive brain cancer with poor prognosis.
  • Mutations in the Kirsten rat sarcoma virus (KRAS) gene are common in GBM and drive cellular signaling.
  • MicroRNAs (miRNAs) are emerging as key regulators within the KRAS signaling pathway.

Purpose of the Study:

  • To investigate the interplay between KRAS and miRNAs in GBM.
  • To explore how KRAS signaling influences miRNA expression and vice versa.
  • To examine the role of this interaction in oncogene-induced senescence (OIS) and tumor progression.

Main Methods:

  • Identification of specific miRNAs targeting KRAS mRNA.
  • Analysis of downstream signaling cascades affected by KRAS and miRNAs.
  • Investigation of feedback loops between KRAS-activated pathways and miRNA levels.

Main Results:

  • Certain miRNAs were identified that directly target KRAS.
  • A feedback loop was established where KRAS activation modulates specific miRNA levels.
  • These interactions are implicated in bypassing oncogene-induced senescence (OIS).

Conclusions:

  • The miRNA-KRAS connection is a critical molecular mechanism in GBM.
  • This interaction influences cell regulation, survival, and tumor progression.
  • Targeting the miRNA-KRAS axis offers a potential avenue for innovative GBM therapies.
Keywords:
GBMKRAS genegliomagenesismiRNAtargetstherapy

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