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Knowledge Mapping of Osteoimmunology:A Bibliometric Study.

Ming-Zhou Chen1, Sheng-Tao Wang1, Dong-Xu Chen1

  • 1Department of Joint Surgery and Sports Medicine,Nanxishan Hospital of Guangxi Zhuang Autonomous Region,Guilin,Guangxi 541002,China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|January 8, 2025
PubMed
Summary

This bibliometric study reveals a growing research interest in osteoimmunology, with China leading publications. Key areas include immune cell signaling in bone, related diseases, and therapeutic strategies, highlighting macrophage polarization and bone regeneration as emerging hotspots.

Keywords:
bibliometricsbone biomaterialbone regenerationmacrophage polarizationosteoimmunologytherapy

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Area of Science:

  • Osteoimmunology research.
  • Bibliometric analysis of scientific literature.

Background:

  • Osteoimmunology integrates the study of bone biology and immunology.
  • Understanding research trends is crucial for future scientific advancement.

Purpose of the Study:

  • To analyze the research status and identify future hotspots in osteoimmunology.
  • To provide a bibliometric overview of publications from 2002 to 2022.

Main Methods:

  • Bibliometric analysis using VOSviewer, CiteSpace, and R.
  • Data retrieved from Web of Science Core Collection (2002-2022).
  • Analysis of countries, institutions, authors, journals, keywords, and references.

Main Results:

  • 812 articles published, with a consistent annual increase.
  • China, USA, and Japan are leading countries; Sichuan University leads institutions.
  • Frontiers in Immunology is the most prolific journal; Takayanagi H is a highly cited author.
  • Research focuses on bone immunity signaling, disease mechanisms, and treatments.
  • Recent hotspots include macrophage polarization, bone biomaterials, and regeneration.

Conclusions:

  • Bibliometric analysis provides a comprehensive overview of osteoimmunology research.
  • Identified trends and hotspots offer guidance for future research directions.
  • The field is dynamic, with increasing focus on therapeutic applications and regenerative medicine.