Related Experiment Video

Updated: Jun 3, 2025

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
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Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

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Immune Checkpoint Inhibitor-Related Acute Kidney Injury: Management and Challenges

Nada Youssef1, Ala Abudayyeh2

  • 1Section of Nephrology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

American Journal of Nephrology
|January 8, 2025
PubMed
Abstract

Insights

Immune checkpoint inhibitor-acute kidney injury (ICI-AKI) is a serious side effect of cancer treatment. Acute tubulointerstitial nephritis is most common, treated with corticosteroids, but resuming ICIs requires careful case-by-case evaluation.

Area of Science:

  • Oncology
  • Nephrology
  • Immunology

Background:

  • Immune checkpoint inhibitors (ICIs) are widely used for cancer treatment.
  • Adverse events, including kidney injury (ICI-AKI), can occur.
  • Limited data exist for managing ICI-AKI and resuming ICIs post-injury.

Purpose of the Study:

  • To review current understanding of ICI-AKI.
  • To discuss management strategies for ICI-AKI.
  • To explore the safety of resuming ICIs after ICI-AKI.

Main Methods:

  • Literature review of ICI-AKI.
  • Analysis of treatment approaches for ICI-AKI.
  • Discussion of clinical decision-making for ICI re-challenge.

Main Results:

  • Acute tubulointerstitial nephritis is the most frequent ICI-AKI pathology.
  • Corticosteroids are the primary treatment for ICI-ATIN.
  • Rituximab is often used for ICI-related glomerulonephritis.

Conclusions:

  • ICI-AKI management is challenging.
  • Treatment decisions for ICI-AKI and re-challenge should be individualized.
  • Further prospective studies are needed to guide ICI-AKI management.
Keywords:
Acute interstitial nephritisAcute renal failureGlomerulonephritisImmune checkpoint inhibitorRituximab

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