Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

1.1K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.1K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

171
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
171
Physiological Control of Respiration01:23

Physiological Control of Respiration

1.9K
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
1.9K
Assessment of Ventilation I: Respiratory Rate01:20

Assessment of Ventilation I: Respiratory Rate

996
Assessment of Ventilation
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation:
996
Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

1.0K
Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
1.0K
Assessment of Ventilation II: Respiratory Depth and Rhythm01:29

Assessment of Ventilation II: Respiratory Depth and Rhythm

1.4K
Respiratory Depth
Respiratory depth measures the volume of air inhaled or exhaled during a breath. It can vary from shallow to deep and typically remains consistent when a person is at rest or asleep. Occasionally, individuals will automatically inhale deeply, known as sighing, which inflates the lungs with more air than normal breathing.
To assess respiratory depth, observe the degree of chest excursion or movement:
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Critical appraisal of open lung ventilation strategies in thoracic surgery: the role of PEEP and recruitment maneuvers.

Journal of thoracic disease·2026
Same author

Embracing Enhanced Recovery After Cardiac Surgery Program.

Cardiology clinics·2026
Same author

Management Algorithm for Vasoplegic Shock after Cardiac Surgery: An Interdisciplinary Collaboration.

The Annals of thoracic surgery·2026
Same author

The effect of a multifaceted intervention on post-operative opioid use after orthopedic and spine surgery: Results of a before-after pilot study.

Journal of opioid management·2026
Same author

2026 American Association for Thoracic Surgery Expert Consensus Document: Diagnosis and management of heparin-induced thrombocytopenia in patients who undergo cardiac surgery.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Ethical Challenges of Extracorporeal Membrane Oxygenation: Enhanced Recovery After Surgery Cardiac Society Consensus on Key Issues and Practical Recommendations.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026

Related Experiment Video

Updated: Jun 3, 2025

A Model to Simulate Clinically Relevant Hypoxia in Humans
09:54

A Model to Simulate Clinically Relevant Hypoxia in Humans

Published on: December 22, 2016

8.8K

Preoperative Multivariable Model for Risk Stratification of Hypoxemia During One-Lung Ventilation.

Andres Zorrilla-Vaca1,2, Michael C Grant3, Laura Mendez-Pino4

  • 1From the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

Anesthesia and Analgesia
|January 8, 2025
PubMed
Summary

A new risk model uses preoperative clinical data to predict hypoxemia during one-lung ventilation (OLV). This tool helps stratify patient risk before thoracic surgery, improving patient safety.

More Related Videos

Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model
08:51

Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model

Published on: November 11, 2022

1.4K
A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery
09:07

A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery

Published on: September 9, 2022

3.7K

Related Experiment Videos

Last Updated: Jun 3, 2025

A Model to Simulate Clinically Relevant Hypoxia in Humans
09:54

A Model to Simulate Clinically Relevant Hypoxia in Humans

Published on: December 22, 2016

8.8K
Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model
08:51

Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model

Published on: November 11, 2022

1.4K
A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery
09:07

A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery

Published on: September 9, 2022

3.7K

Area of Science:

  • Anesthesiology and Critical Care Medicine
  • Thoracic Surgery
  • Respiratory Physiology

Background:

  • Hypoxemia is a common complication during one-lung ventilation (OLV) in thoracic surgery.
  • Existing methods like lung perfusion scans for predicting hypoxemia are complex and costly.
  • A need exists for preoperative risk stratification models for intraoperative hypoxemia.

Purpose of the Study:

  • To develop and validate a preoperative risk stratification model for hypoxemia during OLV.
  • To identify key clinical variables predictive of intraoperative hypoxemia.
  • To provide a tool for better patient risk assessment before thoracic procedures.

Main Methods:

  • Retrospective cohort study of 3228 patients undergoing lung resections with OLV (2017-2022).
  • Demographic and clinical data were analyzed using stepwise logistic regression.
  • A risk score model was developed and internally validated using AUC with bootstrapping.

Main Results:

  • The incidence of hypoxemia during OLV was 8.9%.
  • Nine risk factors were identified, including low preoperative SpO2, low hemoglobin, older age, male sex, obesity, diabetes, congestive heart failure, hypertension, and right-sided surgery.
  • The developed model demonstrated moderate discrimination (AUC 0.708) and identified optimal risk thresholds.

Conclusions:

  • Preoperative clinical variables can effectively stratify hypoxemia risk during OLV.
  • The developed risk model is well-calibrated, offering a practical tool for risk assessment.
  • Further prospective studies are recommended to explore the accuracy of preoperative risk stratification models.