Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Clinical Trials

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

Nursing Clinical Information System

Nursing Clinical Information System

Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Randomized Controlled Trial of No Routine Gastric Residual Monitoring to Guide Enteral Feeding in PICUs: Statistical Analysis Plan for the GASTRIC-PICU Trial.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026

Same author

Gastric Residual Volume Assessment in Critically Ill Children: The GASTRIC-PICU Randomized Clinical Trial.

JAMA·2026

Same author

Low concentration atropine eye drops and progression of myopia in children: multicentre placebo controlled, double masked, randomised trial in the UK (CHAMP-UK).

BMJ (Clinical research ed.)·2026

Same author

Randomised multiple centre trial of conservative versus liberal fluid administration for children receiving a kidney transplant (LIMITS): clinical trial protocol.

BMJ open·2026

Same author

Reflections on and recommendations from the OCEANIC study CYP and parent advisory group: a Patient and Public Involvement and Engagement case study.

Research involvement and engagement·2026

Same author

Real-time prediction of cardiorespiratory deterioration during paediatric critical care transport using interpretable machine learning.

PLOS digital health·2026

Search research articles

Related Experiment Video

Updated: Jun 3, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Developing an adaptive paediatric intensive care unit platform trial with key stakeholders: a qualitative study.

Tracy Karen Mitchell¹, Julie C Menzies², Padmanabhan Ramnarayan³

¹Public Health, Policy and Systems, University of Liverpool, Liverpool, UK Tracy.Mitchell@Liverpool.ac.uk.

|January 8, 2025

Summary

This study found that young people, parents, and pediatric intensive care unit (PICU) staff found the proposed adaptive platform trial acceptable. Their input will help design a family-centered trial to improve critically ill children's treatment.

Keywords:

Adolescent Clinical Trial PAEDIATRICS Paediatric intensive & critical care QUALITATIVE RESEARCH Randomized Controlled Trial

More Related Videos

Development and Implementation of a Multi-Disciplinary Technology Enhanced Care Pathway for Youth and Adults with Concussion

Development and Implementation of a Multi-Disciplinary Technology Enhanced Care Pathway for Youth and Adults with Concussion

Published on: January 20, 2019

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring

Published on: July 14, 2023

Related Experiment Videos

Last Updated: Jun 3, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Development and Implementation of a Multi-Disciplinary Technology Enhanced Care Pathway for Youth and Adults with Concussion

Development and Implementation of a Multi-Disciplinary Technology Enhanced Care Pathway for Youth and Adults with Concussion

Published on: January 20, 2019

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring

Published on: July 14, 2023

Area of Science:

Pediatric Intensive Care
Clinical Trial Design
Qualitative Research

Background:

Platform trials accelerate treatment discovery in adults, as seen during COVID-19.
Adaptive platform trials offer efficient testing of multiple interventions.
Paediatric intensive care (PICU) needs innovative trial designs.

Purpose of the Study:

To inform the design of the UK's first adaptive platform trial in PICU.
To incorporate perspectives of young patients, parents/carers, and PICU staff.
To ensure a family-centered and operationalizable trial protocol.

Main Methods:

Qualitative study using semistructured focus groups.
Reflexive thematic analysis of collected data.
Involved 86 participants: 18 young people, 15 parents/carers, 53 PICU staff.

Main Results:

Stakeholders found the proposed PICU platform trial acceptable.
Key design insights include broad eligibility, prioritizing child quality of life and survival outcomes.
Recommendations provided for governance and overcoming trial challenges.

Conclusions:

The proposed adaptive PICU platform trial is acceptable to key stakeholders.
Stakeholder input ensures a rigorous yet family-centered design.
Findings inform a protocol to generate high-quality evidence for critically ill children.