Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

71
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
71
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

93
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
93
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

386
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
386
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

334
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
334
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

70
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
70
Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

163
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
163

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perioperative outcomes of robotic-assisted liver surgery: A comparison between patients with and without previous abdominal surgery.

Surgery open science·2026
Same author

Conversion to LCP Tacrolimus Mitigates Calcineurin-Induced Nephrotoxicity in Patients After Liver Transplantation.

Clinical transplantation·2026
Same author

[Esophageal NEN: update on diagnostics and surgical treatment].

Chirurgie (Heidelberg, Germany)·2026
Same author

CT-based vascular invasion in pancreatic ductal adenocarcinoma compared with intraoperative and histological findings.

Insights into imaging·2026
Same author

Performance of GPT-based large language models in hepatocellular carcinoma stratification: liver function assessment, BCLC staging, and treatment recommendations.

Scientific reports·2026
Same author

Macrophages in Intestinal Wound Healing: Dichotomous Effects and Therapeutic Opportunities.

International journal of molecular sciences·2026
Same journal

The Prevalence of Hospitalized Cases of Necrotizing Fasciitis: Anatomical Distribution, Amputations, and In-Hospital Mortality, 2019-2024.

Deutsches Arzteblatt international·2026
Same journal

Subclinical Atrial Fibrillation: Detection, Stroke Risk, and Treatment.

Deutsches Arzteblatt international·2026
Same journal

Fewer Premature Births After Assisted Reproduction.

Deutsches Arzteblatt international·2026
Same journal

Femoral Artery Pseudoaneurysm Due to Stent Fracture in PAOD.

Deutsches Arzteblatt international·2026
Same journal

Pain-Adapted Full Weight-bearing After Ankle Fracture Surgery: A Multicenter, Pragmatic, Single-armed Prospective Study.

Deutsches Arzteblatt international·2026
Same journal

Popliteal Artery Entrapment Syndrome.

Deutsches Arzteblatt international·2026
See all related articles

Related Experiment Video

Updated: Jun 3, 2025

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

9.9K

Acute-on-Chronic Liver Failure.

Jonel Trebicka1, Michael Praktiknjo, Kai-Henrik Peiffer

  • 1Department of Medicine B, University Hospital Münster (UKM), Münster, Germany; Department of General, Abdominal and Transplantation Surgery, University Hospital Münster (UKM), Münster, Germany.

Deutsches Arzteblatt International
|January 8, 2025
PubMed
Summary
This summary is machine-generated.

Acute on chronic liver failure (ACLF) is a severe complication of cirrhosis with high mortality. Liver transplantation is the only cure, but patient selection remains a challenge due to limited data.

More Related Videos

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury
07:27

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

Published on: October 21, 2017

11.7K
Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

11.2K

Related Experiment Videos

Last Updated: Jun 3, 2025

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

9.9K
The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury
07:27

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

Published on: October 21, 2017

11.7K
Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

11.2K

Area of Science:

  • Hepatology
  • Critical Care Medicine
  • Transplantation Surgery

Background:

  • Cirrhosis, the end stage of chronic liver disease, frequently leads to portal hypertension and acute on chronic liver failure (ACLF).
  • ACLF is characterized by acute decompensation and failure of multiple organ systems, including the liver, kidneys, and lungs, or hepatic encephalopathy.
  • Cirrhosis impacts approximately 1% of hospital admissions in Germany, contributing to an estimated 1 million deaths globally each year.

Purpose of the Study:

  • To review the current understanding of acute on chronic liver failure (ACLF) in the context of liver cirrhosis.
  • To highlight the challenges and potential future directions in managing ACLF, particularly concerning treatment and transplantation.

Main Methods:

  • A selective literature search was conducted in the NCBI database using keywords "liver cirrhosis" and "ACLF."
  • International publications and relevant clinical guidelines published up to June 2024 were included in the review.

Main Results:

  • ACLF affects 35% of patients hospitalized for decompensated cirrhosis, carrying a significant 28-day mortality rate of 45%.
  • Common precipitating factors for ACLF include infection, alcohol overuse, bleeding, and drug-induced encephalopathy.
  • Currently, no specific drugs or treatments are approved for ACLF itself; management focuses on addressing the underlying etiology and precipitating factors.

Conclusions:

  • Liver transplantation represents the sole curative treatment for ACLF but is limited by a narrow therapeutic window and frequent contraindications.
  • There is a critical need for prospective data to improve patient selection for liver transplantation and enhance post-transplantation survival rates.