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Related Experiment Videos

Problems associated with indwelling central venous catheters.

P J Darbyshire, N C Weightman, D C Speller

    Archives of Disease in Childhood
    |February 1, 1985
    PubMed
    Summary
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    Central venous catheters like Broviac or Hickman are common in cancer patients, with infections occurring frequently, especially with intensive use. However, most infections were treatable, and mechanical issues were more common reasons for removal.

    Area of Science:

    • Medical Science
    • Oncology
    • Infectious Diseases

    Background:

    • Central venous catheters (CVCs) are essential for managing patients with hematological and neoplastic diseases.
    • Indications for CVC insertion include young age, intensive treatment regimens, and patient psychological factors.

    Purpose of the Study:

    • To evaluate the incidence, characteristics, and outcomes of infections associated with Broviac or Hickman indwelling central venous catheters in patients with hematological and neoplastic diseases.
    • To compare infection rates related to intensive versus light catheter use.

    Main Methods:

    • A retrospective analysis of 49 Broviac or Hickman catheters inserted in 36 patients.
    • Documentation of infection episodes, causative organisms, treatment, and catheter removal reasons.

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    Main Results:

    • Sixteen patients experienced 29 catheter-related bloodstream infections (0.68 episodes per 100 catheter days).
    • Infections were significantly more frequent with intensive catheter use.
    • Coagulase-negative staphylococci were the most common pathogens (51%); 72% of infections were successfully treated with antibiotics, with single-strain infections being easier to eradicate than multiple-strain infections.
    • Mechanical complications were a more frequent reason for catheter removal than infection.

    Conclusions:

    • Catheter-related infections are a significant concern in this patient population, particularly with intensive use.
    • While antibiotic treatment is often effective, preventative strategies and management of mechanical complications are crucial.
    • Catheter-related infections did not lead to mortality in this study cohort.