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CD36 in liver diseases
1Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Department of Infectious Diseases, Institute for Viral Hepatitis, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Hepatology Communications
|January 8, 2025
Summary
Cluster of differentiation 36 (CD36) impacts liver health by regulating lipid metabolism and inflammation. Targeting CD36 offers a promising therapeutic strategy for various liver diseases, including fatty liver and cancer.
Area of Science:
- Hepatology
- Immunology
- Molecular Biology
Background:
- Cluster of differentiation 36 (CD36) is a multifunctional transmembrane glycoprotein.
- CD36 recognizes diverse ligands including fatty acids and pathogen-associated molecular patterns.
- It is expressed in liver cells like hepatocytes and Kupffer cells (KCs).
Purpose of the Study:
- To review the structural properties, expression, and functions of CD36 in liver pathophysiology.
- To explore CD36's role in liver diseases such as nonalcoholic fatty liver disease (NAFLD), NASH, and viral hepatitis.
- To highlight CD36 as a potential therapeutic target for liver disease treatment.
Main Methods:
- Literature review of studies on CD36.
- Analysis of CD36's role in lipid metabolism, inflammation, and oxidative stress in the liver.
- Examination of CD36's involvement in the pathogenesis of liver diseases.
Main Results:
- CD36 plays a critical role in liver lipid metabolism, inflammation, and oxidative stress.
- Evidence links CD36 to the development of NAFLD, NASH, inflammatory liver injury, hepatitis B/C, fibrosis, and liver cancer.
- CD36's diverse ligand-binding capabilities contribute to its multifaceted roles.
Conclusions:
- CD36 is a key player in liver pathophysiology with significant implications for disease development.
- Targeting CD36 presents a promising therapeutic avenue for preventing and treating a spectrum of liver diseases.
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